Browse > Article
http://dx.doi.org/10.3348/kjr.2015.16.6.1188

Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part II. Statistical Methods of Meta-Analysis  

Lee, Juneyoung (Department of Biostatistics, Korea University College of Medicine)
Kim, Kyung Won (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
Choi, Sang Hyun (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
Huh, Jimi (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
Park, Seong Ho (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
Publication Information
Korean Journal of Radiology / v.16, no.6, 2015 , pp. 1188-1196 More about this Journal
Abstract
Meta-analysis of diagnostic test accuracy studies differs from the usual meta-analysis of therapeutic/interventional studies in that, it is required to simultaneously analyze a pair of two outcome measures such as sensitivity and specificity, instead of a single outcome. Since sensitivity and specificity are generally inversely correlated and could be affected by a threshold effect, more sophisticated statistical methods are required for the meta-analysis of diagnostic test accuracy. Hierarchical models including the bivariate model and the hierarchical summary receiver operating characteristic model are increasingly being accepted as standard methods for meta-analysis of diagnostic test accuracy studies. We provide a conceptual review of statistical methods currently used and recommended for meta-analysis of diagnostic test accuracy studies. This article could serve as a methodological reference for those who perform systematic review and meta-analysis of diagnostic test accuracy studies.
Keywords
Systematic review; Meta-analysis; Diagnostic test accuracy;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Dinnes J, Deeks J, Kirby J, Roderick P. A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy. Health Technol Assess 2005;9:1-113, iii
2 Irwig L, Tosteson AN, Gatsonis C, Lau J, Colditz G, Chalmers TC, et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med 1994;120:667-676   DOI
3 Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 2005;58:982-990   DOI
4 Zamora J, Abraira V, Muriel A, Khan K, Coomarasamy A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31   DOI
5 Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: dataanalytic approaches and some additional considerations. Stat Med 1993;12:1293-1316   DOI
6 Littenberg B, Moses LE. Estimating diagnostic accuracy from multiple conflicting reports: a new meta-analytic method. Med Decis Making 1993;13:313-321   DOI
7 Rutter CM, Gatsonis CA. A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Stat Med 2001;20:2865-2884   DOI
8 Harbord RM, Whiting P, Sterne JA, Egger M, Deeks JJ, Shang A, et al. An empirical comparison of methods for metaanalysis of diagnostic accuracy showed hierarchical models are necessary. J Clin Epidemiol 2008;61:1095-1103   DOI
9 Kim KW, Lee J, Choi SH, Huh J, Park SH. Systematic review and meta-analysis of studies evaluating diagnostic test accuracy: a practical review for clinical researchers--part i. general guidance and tips. Korean J Radiol 2015;16:1175-1187   DOI
10 Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560   DOI
11 Ochodo EA, Reitsma JB, Bossuyt PM, Leeflang MM. Survey revealed a lack of clarity about recommended methods for meta-analysis of diagnostic accuracy data. J Clin Epidemiol 2013;66:1281-1288   DOI
12 Devillé WL, Buntinx F, Bouter LM, Montori VM, de Vet HC, van der Windt DA, et al. Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Med Res Methodol 2002;2:9   DOI
13 Dodd JD. Evidence-based practice in radiology: steps 3 and 4--appraise and apply diagnostic radiology literature. Radiology 2007;242:342-354   DOI
14 Leeflang MM, Deeks JJ, Gatsonis C, Bossuyt PM; Cochrane Diagnostic Test Accuracy Working Group. Systematic reviews of diagnostic test accuracy. Ann Intern Med 2008;149:889-897   DOI
15 Macaskill P, Gatsonis C, Deeks JJ, Harbord RM, Takwoingi Y. Chapter 10: Analysing and Presenting Results. In: Deeks JJ, Bossuyt PM, Gatsonis C, eds. Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0. The Cochrane Collaboration, 2010. Available from: http://srdta.cochrane.org/
16 Kim KW, Park SH, Pyo J, Yoon SH, Byun JH, Lee MG, et al. Imaging features to distinguish malignant and benign branch-duct type intraductal papillary mucinous neoplasms of the pancreas: a meta-analysis. Ann Surg 2014;259:72-81   DOI
17 Trikalinos TA, Balion CM, Coleman CI, Griffith L, Santaguida PL, Vandermeer B, et al. Chapter 8: meta-analysis of test performance when there is a "gold standard". J Gen Intern Med 2012;27 Suppl 1:S56-S66   DOI
18 DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-188   DOI
19 Bossuyt P, Davenport C, Deeks J, Hyde C, Leeflang M, Scholten R. Chapter 11: Interpreting results and drawing conclusions. In: Deeks JJ, Bossuyt PM, Gatsonis C, eds. Cochrane handbook for systematic reviews of diagnostic test accuracy version 0.9. The Cochrane Collaboration, 2013. Available from: http://srdta.cochrane.org/
20 Jones CM, Athanasiou T. Diagnostic accuracy meta-analysis: review of an important tool in radiological research and decision making. Br J Radiol 2009;82:441-446   DOI
21 Rutter CM, Gatsonis CA. Regression methods for metaanalysis of diagnostic test data. Acad Radiol 1995;2 Suppl 1:S48-S56; discussion S65-S67, S70-S71 pas
22 Harbord RM, Deeks JJ, Egger M, Whiting P, Sterne JA. A unification of models for meta-analysis of diagnostic accuracy studies. Biostatistics 2007;8:239-251   DOI
23 Walter SD. Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data. Stat Med 2002;21:1237-1256   DOI
24 Harbord RM, Whiting P. Metandi: Meta-analysis of diagnostic accuracy using hierarchical logistic regression. Stata J 2009;9:211-229
25 Doebler P, Holling H. Meta-analysis of diagnostic accuracy (mada). Cran.r-project.org Web site. https://cran.r-project.org/web/packages/mada/vignettes/mada.pdf. Accessed October 5, 2015