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http://dx.doi.org/10.3348/kjr.2015.16.1.125

Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma  

Liu, Yi-Sheng (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Ou, Ming-Ching (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Tsai, Yi-Shan (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Lin, Xi-Zhang (Liver Cancer Collaborative Oncology Group, National Cheng-Kung University Hospital)
Wang, Chien-Kuo (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Tsai, Hong-Ming (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Chuang, Ming-Tsung (Department of Diagnostic Radiology, National Cheng-Kung University Hospital)
Publication Information
Korean Journal of Radiology / v.16, no.1, 2015 , pp. 125-132 More about this Journal
Abstract
Objective: To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). Materials and Methods: A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. Results: No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C was significantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. Conclusion: In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.
Keywords
Chemoembolization; Drug-eluting bead; Hepatocellular carcinoma; Doxorubicin; Microsphere;
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