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http://dx.doi.org/10.3348/kjr.2013.14.3.520

Langerhans Cell Sarcoma in Two Young Children: Imaging Findings on Initial Presentation and Recurrence  

Chung, Woong Do (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Im, Soo Ah (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Chung, Nak Gyun (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Park, Gyeong Sin (Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Publication Information
Korean Journal of Radiology / v.14, no.3, 2013 , pp. 520-524 More about this Journal
Abstract
Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells with malignant cytological features and multi-organ involvement that typically has a poor prognosis. We experienced 2 cases of LCS in children less than 2 years of age and report them based primarily on CT and MR findings. Both children had findings of hepatosplenomegaly with low-attenuation nodular lesions, had multiple lymphadenopathy, and had shown recurrent lesions invading the skull during follow-up after chemotherapy.
Keywords
Langerhans cell sarcoma; Langerhans cell histiocytosis; CT; MR;
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1 Zhao, G, Luo, M, Wu, ZY, Liu, Q, Zhang, B, Gao, RL,Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report, Int J Surg Pathol, 17, 1, 347-353(2009)   DOI
2 Lee, JS, Ko, GH, Kim, HC, Jang, IS, Jeon, KN, Lee, JH,Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report, J Korean Med Sci, 21, 2, 577-580(2006)   DOI
3 Nakayama, M, Takahashi, K, Hori, M, Okumura, T, Saito, M, Yamakawa, M,Langerhans cell sarcoma of the cervical lymph node: a case report and literature review, Auris Nasus Larynx, 37, 3, 750-753(2010)   DOI
4 Luo, B, Pian, B, Peng, Z, Jintao, D, Shixi, L,Pharyngeal tonsil manifestation of Langerhans cells sarcoma: a case report and review of the literature, Int J Pediatr Otorhinolaryngol Extra, 6, 4, 156-158(2011)   DOI
5 Uchida, K, Kobayashi, S, Inukai, T, Noriki, S, Imamura, Y, Nakajima, H,Langerhans cell sarcoma emanating from the upper arm skin: successful treatment by MAID regimen, J Orthop Sci, 13, 5, 89-93(2008)   DOI
6 Henter, JI, Horne, A, Aric처, M, Egeler, RM, Filipovich, AH, Imashuku, S,HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, Pediatr Blood Cancer, 48, 6, 124-131(2007)   DOI
7 Donadieu, J, Chalard, F, Jeziorski, E,Medical management of langerhans cell histiocytosis from diagnosis to treatment, Expert Opin Pharmacother, 13, 7, 1309-1322(2012)   DOI
8 Caruso, S, Miraglia, R, Maruzzelli, L, Luca, A, Gridelli, B,Biliary wall calcification in Langerhans cell histiocytosis: report of two cases, Pediatr Radiol, 38, 8, 791-794(2008)   DOI
9 Pyun, HW, Kim, ME, Kim, JH,CT and MR findings of langerhans cell histiocytois involving the spleen: a case report, J Korean Radiol Soc, 46, 9, 171-174(2002)   DOI
10 Heller, GD, Haller, JO, Berdon, WE, Sane, S, Kleinman, PK,Punctate thymic calcification in infants with untreated Langerhans' cell histiocytosis: report of four new cases, Pediatr Radiol, 29, 10, 813-815(1999)   DOI
11 Yi, G, Yoon, HK, Kim, BK, Kim, KA, Choo, IW,CT findings of orbital langerhans cell histiocytosis, J Korean Radiol Soc, 42, 11, 841-846(2000)   DOI