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http://dx.doi.org/10.3348/kjr.2013.14.3.477

Application of 31P MR Spectroscopy to the Brain Tumors  

Ha, Dong-Ho (Department of Radiology, College of Medicine, Dong-A University)
Choi, Sunseob (Department of Radiology, College of Medicine, Dong-A University)
Oh, Jong Young (Department of Radiology, College of Medicine, Dong-A University)
Yoon, Seong Kuk (Department of Radiology, College of Medicine, Dong-A University)
Kang, Myong Jin (Department of Radiology, College of Medicine, Dong-A University)
Kim, Ki-Uk (Department of Neurosurgery, College of Medicine, Dong-A University)
Publication Information
Korean Journal of Radiology / v.14, no.3, 2013 , pp. 477-486 More about this Journal
Abstract
Objective: To evaluate the clinical feasibility and obtain useful parameters of 31P magnetic resonance spectroscopy (MRS) study for making the differential diagnosis of brain tumors. Materials and Methods: Twenty-eight patients with brain tumorous lesions (22 cases of brain tumor and 6 cases of abscess) and 11 normal volunteers were included. The patients were classified into the astrocytoma group, lymphoma group, metastasis group and the abscess group. We obtained the intracellular pH and the metabolite ratios of phosphomonoesters/ phosophodiesters (PME/PDE), PME/inorganic phosphate (Pi), PDE/Pi, PME/adenosine triphosphate (ATP), PDE/ATP, PME/ phosphocreatine (PCr), PDE/PCr, PCr/ATP, PCr/Pi, and ATP/Pi, and evaluated the statistical significances. Results: The brain tumors had a tendency of alkalization (pH = 7.28 ${\pm}$ 0.27, p = 0.090), especially the pH of the lymphoma was significantly increased (pH = 7.45 ${\pm}$ 0.32, p = 0.013). The brain tumor group showed increased PME/PDE ratio compared with that in the normal control group (p = 0.012). The ratios of PME/PDE, PDE/Pi, PME/PCr and PDE/PCr showed statistically significant differences between each brain lesion groups (p < 0.05). The astrocytoma showed an increased PME/PDE and PME/PCr ratio. The ratios of PDE/Pi, PME/PCr, and PDE/PCr in lymphoma group were lower than those in the control group and astrocytoma group. The metastasis group showed an increased PME/PDE ratio, compared with that in the normal control group. Conclusion: We have obtained the clinically applicable 31P MRS, and the pH, PME/PDE, PDE/Pi, PME/PCr, and PDE/PCr ratios are helpful for differentiating among the different types of brain tumors.
Keywords
Magnetic resonance imaging; MRS; Brain; Tumor;
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1 Stubbs, M, Rodrigues, LM, Gusterson, BA, Griffiths, JR,Monitoring tumor growth and regression by 31P magnetic resonance spectroscopy, Adv Enzyme Regul, 30, 1, 217-230(1990)   DOI
2 Podo, F, Canevari, S, Canese, R, Pisanu, ME, Ricci, A, Iorio, E,MR evaluation of response to targeted treatment in cancer cells, NMR Biomed, 24, 2, 648-672(2011)
3 Park, JM, Park, JH,Human in-vivo 31P MR spectroscopy of benign and malignant breast tumors, Korean J Radiol, 2, 3, 80-86(2001)   DOI
4 Cohen, JS,Phospholipid and energy metabolism of cancer cells monitored by 31P magnetic resonance spectroscopy: possible clinical significance, Mayo Clin Proc, 63, 4, 1199-1207(1988)   DOI
5 Lehnhardt, FG, Rohn, G, Ernestus, RI, Grune, M, Hoehn, M,1H- and (31)P-MR spectroscopy of primary and recurrent human brain tumors in vitro: malignancy-characteristic profiles of water soluble and lipophilic spectral components, NMR Biomed, 14, 5, 307-317(2001)   DOI
6 Heiss, WD, Heindel, W, Herholz, K, Rudolf, J, Bunke, J, Jeske, J,Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors, J Nucl Med, 31, 6, 302-310(1990)
7 Hirakawa, K, Naruse, S, Higuchi, T, Horikawa, Y, Tanaka, C, Ebisu, T,The investigation of experimental brain tumours using 31P-MRS and 1H-MRI, Acta Neurochir Suppl (Wien), 43, 7, 140-144(1988)
8 Maintz, D, Heindel, W, Kugel, H, Jaeger, R, Lackner, KJ,Phosphorus-31 MR spectroscopy of normal adult human brain and brain tumours, NMR Biomed, 15, 8, 18-27(2002)   DOI
9 Arias-Mendoza, F, Payne, GS, Zakian, KL, Schwarz, AJ, Stubbs, M, Stoyanova, R,In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial, NMR Biomed, 19, 9, 504-512(2006)   DOI
10 Ng, TC, Majors, AW, Vijayakumar, S, Baldwin, NJ, Thomas, FJ, Koumoundouros, I,Human neoplasm pH and response to radiation therapy: P-31 MR spectroscopy studies in situ, Radiology, 170, 10, 875-878(1989)   DOI
11 Esteve, F, Grand, S, Rubin, C, Hoffmann, D, Pasquier, B, Graveron-Demilly, D,MR spectroscopy of bilateral thalamic gliomas, AJNR Am J Neuroradiol, 20, 11, 876-881(1999)
12 Oberhaensli, RD, Galloway, GJ, Hilton-Jones, D, Bore, PJ, Styles, P, Rajagopalan, B,The study of human organs by phosphorus-31 topical magnetic resonance spectroscopy, Br J Radiol, 60, 12, 367-373(1987)   DOI
13 Madden, A, Leach, MO, Sharp, JC, Collins, DJ, Easton, D,A quantitative analysis of the accuracy of in vivo pH measurements with 31P NMR spectroscopy: assessment of pH measurement methodology, NMR Biomed, 4, 13, 1-11(1991)   DOI
14 Gillies, RJ, Raghunand, N, Karczmar, GS, Bhujwalla, ZM,MRI of the tumor microenvironment, J Magn Reson Imaging, 16, 14, 430-450(2002)   DOI
15 Griffiths, JR,Are cancer cells acidic?, Br J Cancer, 64, 15, 425-427(1991)   DOI
16 Negendank, W,Studies of human tumors by MRS: a review, NMR Biomed, 5, 16, 303-324(1992)   DOI
17 Hubesch, B, Sappey-Marinier, D, Roth, K, Meyerhoff, DJ, Matson, GB, Weiner, MW,P-31 MR spectroscopy of normal human brain and brain tumors, Radiology, 174, 17, 401-409(1990)   DOI
18 Okada, Y, Kloiber, O, Hossmann, KA,Regional metabolism in experimental brain tumors in cats: relationship with acid/base, water, and electrolyte homeostasis, J Neurosurg, 77, 18, 917-926(1992)   DOI
19 Albers, MJ, Krieger, MD, Gonzalez-Gomez, I, Gilles, FH, McComb, JG, Nelson, MD,Proton-decoupled 31P MRS in untreated pediatric brain tumors, Magn Reson Med, 53, 19, 22-29(2005)   DOI
20 Neeman, M, Degani, H,Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy, Cancer Res, 49, 20, 589-594(1989)
21 Aisen, AM, Chenevert, TL,MR spectroscopy: clinical perspective, Radiology, 173, 21, 593-599(1989)   DOI
22 Podo, F,Tumour phospholipid metabolism, NMR Biomed, 12, 22, 413-439(1999)   DOI
23 Abraha, A, Shim, H, Wehrle, JP, Glickson, JD,Inhibition of tumor cell proliferation by dexamethasone: 31P NMR studies of RIF-1 fibrosarcoma cells perfused in vitro, NMR Biomed, 9, 23, 173-178(1996)   DOI
24 Arnold, DL, Emrich, JF, Shoubridge, EA, Villemure, JG, Feindel, W,Characterization of astrocytomas, meningiomas, and pituitary adenomas by phosphorus magnetic resonance spectroscopy, J Neurosurg, 74, 24, 447-453(1991)   DOI
25 Skoch, A, Jiru, F, Bunke, J,Spectroscopic imaging: basic principles, Eur J Radiol, 67, 28, 230-239(2008)   DOI
26 Kemp, GJ, Meyerspeer, M, Moser, E,Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review, NMR Biomed, 20, 25, 555-565(2007)   DOI
27 Burkhard, T, Herzog, C, Linzbach, S, Spyridopoulos, I, Huebner, F, Vogl, TJ,Cardiac (31)P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction--preliminary results, Eur J Radiol, 71, 26, 69-74(2009)   DOI
28 Schulz, UG, Blamire, AM, Davies, P, Styles, P, Rothwell, PM,Normal cortical energy metabolism in migrainous stroke: A 31P-MR spectroscopy study, Stroke, 40, 27, 3740-3744(2009)   DOI
29 Keevil, SF, Newbold, MC,The performance of volume selection sequences for in vivo NMR spectroscopy: implications for quantitative MRS, Magn Reson Imaging, 19, 29, 1217-1226(2001)   DOI