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http://dx.doi.org/10.3348/kjr.2013.14.1.102

Preliminary Experience Using Dynamic MRI at 3.0 Tesla for Evaluation of Soft Tissue Tumors  

Park, Michael Yong (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Jee, Won-Hee (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Kim, Sun Ki (Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Lee, So-Yeon (Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Jung, Joon-Yong (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
Publication Information
Korean Journal of Radiology / v.14, no.1, 2013 , pp. 102-109 More about this Journal
Abstract
Objective: We aimed to evaluate the use of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) at 3.0 T for differentiating the benign from malignant soft tissue tumors. Also we aimed to assess whether the shorter length of DCEMRI protocols are adequate, and to evaluate the effect of temporal resolution. Materials and Methods: Dynamic contrast-enhanced magnetic resonance imaging, at 3.0 T with a 1 second temporal resolution in 13 patients with pathologically confirmed soft tissue tumors, was analyzed. Visual assessment of time-signal curves, subtraction images, maximal relative enhancement at the first (maximal peak enhancement [Emax]/1) and second (Emax/2) minutes, Emax, steepest slope calculated by using various time intervals (5, 30, 60 seconds), and the start of dynamic enhancement were analyzed. Results: The 13 tumors were comprised of seven benign and six malignant soft tissue neoplasms. Washout on time-signal curves was seen on three (50%) malignant tumors and one (14%) benign one. The most discriminating DCE-MRI parameter was the steepest slope calculated, by using at 5-second intervals, followed by Emax/1 and Emax/2. All of the steepest slope values occurred within 2 minutes of the dynamic study. Start of dynamic enhancement did not show a significant difference, but no malignant tumor rendered a value greater than 14 seconds. Conclusion: The steepest slope and early relative enhancement have the potential for differentiating benign from malignant soft tissue tumors. Short-length rather than long-length DCE-MRI protocol may be adequate for our purpose. The steepest slope parameters require a short temporal resolution, while maximal peak enhancement parameter may be more optimal for a longer temporal resolution.
Keywords
Dynamic contrast enhanced MRI; Soft tissue tumor; MRI; Time signal intensity curve; Maximal relative enhancement; Maximal peak enhancement;
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1 Yang, J, Kim, JH, Im, GH, Heo, H, Yoon, S, Lee, J,Evaluation of antiangiogenic effects of a new synthetic candidate drug KR-31831 on xenografted ovarian carcinoma using dynamic contrast enhanced MRI, Korean J Radiol, 12, 18, 602-610(2011)   DOI
2 Pabst, T, Kenn, W, Kaiser, WA, Hahn, D,Understanding why contrast enhancement in dynamic MRI is not reproducible: illustration with a simple phantom, Breast J, 7, 19, 166-170(2001)   DOI
3 Verstraete, KL, Vanzieleghem, B, De Deene, Y, Palmans, H, De Greef, D, Kristoffersen, DT,Static, dynamic and first-pass MR imaging of musculoskeletal lesions using gadodiamide injection, Acta Radiol, 36, 10, 27-36(1995)   DOI
4 Fletcher, BD, Hanna, SL, Fairclough, DL, Gronemeyer, SA,Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy, Radiology, 184, 11, 243-248(1992)   DOI
5 Lang, P, Honda, G, Roberts, T, Vahlensieck, M, Johnston, JO, Rosenau, W,Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates, Radiology, 197, 12, 831-839(1995)   DOI
6 Ma, LD, Frassica, FJ, McCarthy, EF, Bluemke, DA, Zerhouni, EA,Benign and malignant musculoskeletal masses: MR imaging differentiation with rim-to-center differential enhancement ratios, Radiology, 202, 13, 739-744(1997)   DOI
7 Fletcher, BD, Reddick, WE, Taylor, JS,Dynamic MR imaging of musculoskeletal neoplasms, Radiology, 200, 14, 869-872(1996)
8 Lavini, C, de Jonge, MC, van de Sande, MG, Tak, PP, Nederveen, AJ, Maas, M,Pixel-by-pixel analysis of DCE MRI curve patterns and an illustration of its application to the imaging of the musculoskeletal system, Magn Reson Imaging, 25, 15, 604-612(2007)   DOI
9 Lavini, C, Pikaart, BP, de Jonge, MC, Schaap, GR, Maas, M,Region of interest and pixel-by-pixel analysis of dynamic contrast enhanced magnetic resonance imaging parameters and time-intensity curve shapes: a comparison in chondroid tumors, Magn Reson Imaging, 27, 16, 62-68(2009)   DOI
10 Ahn, SJ, An, CS, Koom, WS, Song, HT, Suh, JS,Correlations of 3T DCE-MRI quantitative parameters with microvessel density in a human-colorectal-cancer xenograft mouse model, Korean J Radiol, 12, 17, 722-730(2011)   DOI
11 Verstraete KL, De Deene Y, Roels H, Dierick A, Uyttendaele D, Kunnen M. Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging--parametric "firstpass" images depict tissue vascularization and perfusion. Radiology 1994;192:835-843   DOI
12 van Rijswijk, CS, Geirnaerdt, MJ, Hogendoorn, PC, Taminiau, AH, van Coevorden, F, Zwinderman, AH,Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy, Radiology, 233, 3, 493-502(2004)   DOI
13 Tuncbilek, N, Karakas, HM, Okten, OO,Dynamic contrast enhanced MRI in the differential diagnosis of soft tissue tumors, Eur J Radiol, 53, 4, 500-505(2005)   DOI
14 Carmeliet, P, Jain, RK,Angiogenesis in cancer and other diseases, Nature, 407, 5, 249-257(2000)   DOI
15 Kuhl, CK, Mielcareck, P, Klaschik, S, Leutner, C, Wardelmann, E, Gieseke, J,Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions?, Radiology, 211, 6, 101-110(1999)   DOI
16 van der Woude, HJ, Verstraete, KL, Hogendoorn, PC, Taminiau, AH, Hermans, J, Bloem, JL,Musculoskeletal tumors: does fast dynamic contrast-enhanced subtraction MR imaging contribute to the characterization?, Radiology, 208, 7, 821-828(1998)   DOI
17 Erlemann, R, Reiser, MF, Peters, PE, Vasallo, P, Nommensen, B, Kusnierz-Glaz, CR,Musculoskeletal neoplasms: static and dynamic Gd-DTPA--enhanced MR imaging, Radiology, 171, 1, 767-773(1989)   DOI
18 Kuhl, CK, Schild, HH, Morakkabati, N,Dynamic bilateral contrast-enhanced MR imaging of the breast: trade-off between spatial and temporal resolution, Radiology, 236, 8, 789-800(2005)   DOI
19 Moon, M, Cornfeld, D, Weinreb, J,Dynamic contrast-enhanced breast MR imaging, Magn Reson Imaging Clin N Am, 17, 9, 351-362(2009)   DOI