[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.3348/kjr.2013.14.1.1

Prognostic Significance of Volume-Based PET Parameters in Cancer Patients

Moon, Seung Hwan (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Hyun, Seung Hyup (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choi, Joon Young (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)

Publication Information

Korean Journal of Radiology / v.14, no.1, 2013 , pp. 1-12 More about this Journal

Abstract

Accurate prediction of cancer prognosis before the start of treatment is important since these predictions often affect the choice of treatment. Prognosis is usually based on anatomical staging and other clinical factors. However, the conventional system is not sufficient to accurately and reliably determine prognosis. Metabolic parameters measured by $^{18}F$ -fluorodeoxyglucose (FDG) positron emission tomography (PET) have the potential to provide valuable information regarding prognosis and treatment response evaluation in cancer patients. Among these parameters, volume-based PET parameters such as metabolic tumor volume and total lesion glycolysis are especially promising. However, the measurement of these parameters is significantly affected by the imaging methodology and specific image characteristics, and a standard method for these parameters has not been established. This review introduces volume-based PET parameters as potential prognostic indicators, and highlights methodological considerations for measurement, potential implications, and prospects for further studies.

Keywords

Positron emission tomography; $^{18}F$ -fluorodeoxyglucose; Metabolic tumor volume; Total lesion glycolysis; Prognosisrinogenesis;

Citations & Related Records

Reference

1	Zhu, D, Ma, T, Niu, Z, Zheng, J, Han, A, Zhao, S,Prognostic significance of metabolic parameters measured by F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with small cell lung cancer, Lung Cancer, 73, 62, 332-337(2011) DOI
2	Akhurst, T, Ng, V, Larson, SM, O'Donoghue, JA, O'Neel, J, Erdi, Y,Tumor Burden Assessment with Positron Emission Tomography with, Clin Positron Imaging, 3, 54, 57-65(2000) DOI
3	M O'BRIEN, Robert,A caution regarding rules of thumb for variance inflation factors, Qual Quant, 41, 55, 673-690(2007) DOI
4	Chan, WK, Mak, HK, Huang, B, Yeung, DW, Kwong, DL, Khong, PL,Nasopharyngeal carcinoma: relationship between F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification, Nucl Med Commun, 31, 56, 206-210(2010) DOI
5	Chang, KP, Tsang, NM, Liao, CT, Hsu, CL, Chung, MJ, Lo, CW,Prognostic significance of F-FDG PET parameters and plasma Epstein-Barr virus DNA load in patients with nasopharyngeal carcinoma, J Nucl Med, 53, 57, 21-28(2012) DOI
6	Gu, J, Khong, PL, Wang, S, Chan, Q, Law, W, Zhang, J,Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: correlation with FDG-PET/CT, Mol Imaging Biol, 13, 58, 1020-1028(2011) DOI
7	Jansen, JF, Schöder, H, Lee, NY, Stambuk, HE, Wang, Y, Fury, MG,Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [F]FDG-PET, Int J Radiat Oncol Biol Phys, 82, 59, 299-307(2012) DOI
8	Aboagye, EO, Bhujwalla, ZM,Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells, Cancer Res, 59, 60, 80-84(1999)
9	Oh, JR, Seo, JH, Chong, A, Min, JJ, Song, HC, Kim, YC,Whole-body metabolic tumour volume of F-FDG PET/CT improves the prediction of prognosis in small cell lung cancer, Eur J Nucl Med Mol Imaging, 39, 61, 925-935(2012) DOI
10	Brepoels, L, De Saint-Hubert, M, Stroobants, S, Verhoef, G, Balzarini, J, Mortelmans, L,Dose-response relationship in cyclophosphamide-treated B-cell lymphoma xenografts monitored with [F]FDG PET, Eur J Nucl Med Mol Imaging, 37, 47, 1688-1695(2010) DOI
11	Melton, GB, Lavely, WC, Jacene, HA, Schulick, RD, Choti, MA, Wahl, RL,Efficacy of preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography for assessing primary rectal cancer response to neoadjuvant therapy, J Gastrointest Surg, 11, 48, 961-969(2007) DOI
12	Im, HJ, Kim, TS, Park, SY, Min, HS, Kim, JH, Kang, HG,Prediction of tumour necrosis fractions using metabolic and volumetric F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma, Eur J Nucl Med Mol Imaging, 39, 49, 39-49(2012) DOI
13	Roedl, JB, Colen, RR, Holalkere, NS, Fischman, AJ, Choi, NC, Blake, MA,Adenocarcinomas of the esophagus: response to chemoradiotherapy is associated with decrease of metabolic tumor volume as measured on PET-CT. Comparison to histopathologic and clinical response evaluation, Radiother Oncol, 89, 50, 278-286(2008) DOI
14	Arslan, N, Miller, TR, Dehdashti, F, Battafarano, RJ, Siegel, BA,Evaluation of response to neoadjuvant therapy by quantitative 2-deoxy-2-[F]fluoro-D-glucose with positron emission tomography in patients with esophageal cancer, Mol Imaging Biol, 4, 51, 301-310(2002) DOI
15	Ruby, JA, Leibold, T, Akhurst, TJ, Shia, J, Saltz, LB, Mazumdar, M,FDG-PET assessment of rectal cancer response to neoadjuvant chemoradiotherapy is not associated with long-term prognosis: a prospective evaluation, Dis Colon Rectum, 55, 52, 378-386(2012) DOI
16	Edet-Sanson, A, Dubray, B, Doyeux, K, Back, A, Hapdey, S, Modzelewski, R,Serial assessment of FDG-PET FDG uptake and functional volume during radiotherapy (RT) in patients with non-small cell lung cancer (NSCLC), Radiother Oncol, 102, 53, 251-257(2012) DOI
17	Chung, HH, Kwon, HW, Kang, KW, Park, NH, Song, YS, Chung, JK,Prognostic value of preoperative metabolic tumor volume and total lesion glycolysis in patients with epithelial ovarian cancer, Ann Surg Oncol, 19, 39, 1966-1972(2012) DOI
18	Kim, BS, Kim, IJ, Kim, SJ, Nam, NH, Park, KJ, Kim, K,The Prognostic value of the metabolic tumor volume in FIGO stage IA to IIB cervical cancer for tumor recurrence: measured by F-18 FDG PET/CT, Nucl Med Mol Imaging, 45, 40, 36-42(2011) DOI
19	Schaefer, NG, Veit-Haibach, P, Soyka, JD, Steinert, HC, Stahel, RA,Continued pemetrexed and platin-based chemotherapy in patients with malignant pleural mesothelioma (MPM): value of F-FDG-PET/CT, Eur J Radiol, 81, 41, e19-e25(2012) DOI
20	Costelloe, CM, Macapinlac, HA, Madewell, JE, Fitzgerald, NE, Mawlawi, OR, Rohren, EM,F-FDG PET/CT as an indicator of progression-free and overall survival in osteosarcoma, J Nucl Med, 50, 42, 340-347(2009) DOI
21	Kiyohara, S, Nagamachi, S, Wakamatsu, H, Nishii, R, Fujita, S, Futami, S,[Usefulness of metabolic volume and total lesion glycolysis for predicting therapeutic response in cancer therapy by F-FDG PET/CT], Kaku Igaku, 47, 46, 453-461(2010)
22	Yoo, J, Choi, JY, Lee, KT, Heo, JS, Park, SB, Moon, SH,Prognostic significance of volume-based metabolic parameters by F-FDG PET/CT in gallbladder carcinoma, Nucl Med Mol Imaging, 46, 43, 201-206(2012) DOI
23	Lee, HY, Hyun, SH, Lee, KS, Kim, BT, Kim, J, Shim, YM,Volume-based parameter of F-FDG PET/CT in malignant pleural mesothelioma: prediction of therapeutic response and prognostic implications, Ann Surg Oncol, 17, 44, 2787-2794(2010) DOI
24	Kang, H, Lee, HY, Lee, KS, Kim, JH,Imaging-based tumor treatment response evaluation: review of conventional, new, and emerging concepts, Korean J Radiol, 13, 45, 371-390(2012) DOI
25	Liao, S, Penney, BC, Wroblewski, K, Zhang, H, Simon, CA, Kampalath, R,Prognostic value of metabolic tumor burden on F-FDG PET in nonsurgical patients with non-small cell lung cancer, Eur J Nucl Med Mol Imaging, 39, 31, 27-38(2012) DOI
26	Chan, SC, Chang, JT, Lin, CY, Ng, SH, Wang, HM, Liao, CT,Clinical utility of F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification, Nucl Med Commun, 32, 32, 989-996(2011) DOI
27	Chu, KP, Murphy, JD, La, TH, Krakow, TE, Iagaru, A, Graves, EE,Prognostic value of metabolic tumor volume and velocity in predicting head-and-neck cancer outcomes, Int J Radiat Oncol Biol Phys, 83, 33, 1521-1527(2012) DOI
28	La, TH, Filion, EJ, Turnbull, BB, Chu, JN, Lee, P, Nguyen, K,Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer, Int J Radiat Oncol Biol Phys, 74, 34, 1335-1341(2009) DOI
29	Xie, P, Yue, JB, Zhao, HX, Sun, XD, Kong, L, Fu, Z,Prognostic value of F-FDG PET-CT metabolic index for nasopharyngeal carcinoma, J Cancer Res Clin Oncol, 136, 35, 883-889(2010) DOI
30	Choi, KH, Yoo, IR, Han, EJ, Kim, YS,Prognostic Value of Metabolic Tumor Volume Measured by F-FDG PET/CT in Locally Advanced Head and Neck Squamous Cell Carcinomas Treated by Surgery, Nucl Med Mol Imaging, 45, 36, 43-51(2011) DOI
31	Cheebsumon, P, van Velden, FH, Yaqub, M, Frings, V, de Langen, AJ, Hoekstra, OS,Effects of image characteristics on performance of tumor delineation methods: a test-retest assessment, J Nucl Med, 52, 24, 1550-1558(2011) DOI
32	Guillem, JG, Moore, HG, Akhurst, T, Klimstra, DS, Ruo, L, Mazumdar, M,Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: a means for determining longterm outcomes of rectal cancer, J Am Coll Surg, 199, 37, 1-7(2004)
33	Gulec, SA, Suthar, RR, Barot, TC, Pennington, K,The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases undergoing Y selective internal radiation therapy plus chemotherapy, Eur J Nucl Med Mol Imaging, 38, 38, 1289-1295(2011) DOI
34	Hatt, M, Visvikis, D, Albarghach, NM, Tixier, F, Pradier, O, Cheze-le Rest, C,Prognostic value of F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology, Eur J Nucl Med Mol Imaging, 38, 23, 1191-1202(2011) DOI
35	Kim, K, Kim, SJ, Kim, IJ, Kim, YS, Pak, K, Kim, H,Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer, Nucl Med Commun, 33, 25, 613-620(2012) DOI
36	Daisne, JF, Sibomana, M, Bol, A, Doumont, T, Lonneux, M, Grégoire, V,Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: influence of reconstruction algorithms, Radiother Oncol, 69, 26, 247-250(2003) DOI
37	Hatt, M, Le Pogam, A, Visvikis, D, Pradier, O, Cheze Le Rest, C,Impact of partial-volume effect correction on the predictive and prognostic value of baseline F-FDG PET images in esophageal cancer, J Nucl Med, 53, 27, 12-20(2012) DOI
38	Nehmeh, SA, Erdi, YE, Ling, CC, Rosenzweig, KE, Schoder, H, Larson, SM,Effect of respiratory gating on quantifying PET images of lung cancer, J Nucl Med, 43, 28, 876-881(2002)
39	Cheebsumon, P, van Velden, FH, Yaqub, M, Hoekstra, CJ, Velasquez, LM, Hayes, W,Measurement of metabolic tumor volume: static versus dynamic FDG scans, EJNMMI Res, 1, 29, 35(2011) DOI
40	Arslan, N, Tuncel, M, Kuzhan, O, Alagoz, E, Budakoglu, B, Ozet, A,Evaluation of outcome prediction and disease extension by quantitative 2-deoxy-2-F fluoro-D-glucose with positron emission tomography in patients with small cell lung cancer, Ann Nucl Med, 25, 30, 406-413(2011) DOI
41	Zhong, X, Yu, J, Zhang, B, Mu, D, Zhang, W, Li, D,Using F-fluorodeoxyglucose positron emission tomography to estimate the length of gross tumor in patients with squamous cell carcinoma of the esophagus, Int J Radiat Oncol Biol Phys, 73, 16, 136-141(2009) DOI
42	Hyun, SH, Choi, JY, Shim, YM, Kim, K, Lee, SJ, Cho, YS,Prognostic value of metabolic tumor volume measured by F-fluorodeoxyglucose positron emission tomography in patients with esophageal carcinoma, Ann Surg Oncol, 17, 17, 115-122(2010) DOI
43	Cheebsumon, P, Yaqub, M, van Velden, FH, Hoekstra, OS, Lammertsma, AA, Boellaard, R,Impact of [F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology, Eur J Nucl Med Mol Imaging, 38, 18, 2136-2144(2011) DOI
44	Meng, X, Sun, X, Mu, D, Xing, L, Ma, L, Zhang, B,Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, 82, 19, 960-966(2012) DOI
45	Juweid, ME, Stroobants, S, Hoekstra, OS, Mottaghy, FM, Dietlein, M, Guermazi, A,Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma, J Clin Oncol, 25, 20, 571-578(2007) DOI
46	Le Roux, PY, Gastinne, T, Le Gouill, S, Nowak, E, Bodet-Milin, C, Querellou, S,Prognostic value of interim FDG PET/CT in Hodgkin's lymphoma patients treated with interim response-adapted strategy: comparison of International Harmonization Project (IHP), Gallamini and London criteria, Eur J Nucl Med Mol Imaging, 38, 21, 1064-1071(2011) DOI
47	de Jong, PA, van Ufford, HM, Baarslag, HJ, de Haas, MJ, Wittebol, SH, Quekel, LG,CT and F-FDG PET for noninvasive detection of splenic involvement in patients with malignant lymphoma, AJR Am J Roentgenol, 192, 22, 745-753(2009) DOI
48	Takes, RP, Rinaldo, A, Silver, CE, Piccirillo, JF, Haigentz, M, Suárez, C,Future of the TNM classification and staging system in head and neck cancer, Head Neck, 32, 1, 1693-1711(2010) DOI
49	Mirsadraee, S, Oswal, D, Alizadeh, Y, Caulo, A, van Beek, E,The 7th lung cancer TNM classification and staging system: Review of the changes and implications, World J Radiol, 4, 3, 128-134(2012)
50	Lee, P, Weerasuriya, DK, Lavori, PW, Quon, A, Hara, W, Maxim, PG,Metabolic tumor burden predicts for disease progression and death in lung cancer, Int J Radiat Oncol Biol Phys, 69, 2, 328-333(2007) DOI
51	Walters, TK, Zuckerman, J, Nisbet-Smith, A, Hudson, E, Chia, Y, Burke, M,Fine needle aspiration biopsy in the diagnosis and management of fibroadenoma of the breast, Br J Surg, 77, 4, 1215-1217(1990) DOI
52	Chun, YH, Kim, SU, Park, JY, Y Kim, do, Han, KH, Chon, CY,Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma, Eur J Cancer, 47, 5, 2568-2575(2011) DOI
53	Soret, M, Bacharach, SL, Buvat, I,Partial-volume effect in PET tumor imaging, J Nucl Med, 48, 6, 932-945(2007) DOI
54	Vanderhoek, M, Perlman, SB, Jeraj, R,Impact of the definition of peak standardized uptake value on quantification of treatment response, J Nucl Med, 53, 7, 4-11(2012) DOI
55	Larson, SM, Erdi, Y, Akhurst, T, Mazumdar, M, Macapinlac, HA, Finn, RD,Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis, Clin Positron Imaging, 2, 8, 159-171(1999) DOI
56	Moon, SH, Choi, JY, Lee, HJ, Son, YI, Baek, CH, Ahn, YC,Prognostic value of F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume-based metabolic parameters, Head Neck, , 9, (2012)
57	Geets, X, Lee, JA, Bol, A, Lonneux, M, Gregoire, V,A gradient-based method for segmenting FDG-PET images: methodology and validation, Eur J Nucl Med Mol Imaging, 34, 10, 1427-1438(2007) DOI
58	Schaefer, A, Kremp, S, Hellwig, D, Rube, C, Kirsch, CM, Nestle, U,A contrast-oriented algorithm for FDG-PET-based delineation of tumour volumes for the radiotherapy of lung cancer: derivation from phantom measurements and validation in patient data, Eur J Nucl Med Mol Imaging, 35, 11, 1989-1999(2008) DOI
59	Boellaard, R, Krak, NC, Hoekstra, OS, Lammertsma, AA,Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study, J Nucl Med, 45, 13, 1519-1527(2004)
60	van Dalen, JA, Hoffmann, AL, Dicken, V, Vogel, WV, Wiering, B, Ruers, TJ,A novel iterative method for lesion delineation and volumetric quantification with FDG PET, Nucl Med Commun, 28, 12, 485-493(2007) DOI
61	Paulino, AC, Koshy, M, Howell, R, Schuster, D, Davis, LW,Comparison of CT- and FDG-PET-defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer, Int J Radiat Oncol Biol Phys, 61, 14, 1385-1392(2005) DOI
62	MacManus, M, Nestle, U, Rosenzweig, KE, Carrio, I, Messa, C, Belohlavek, O,Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-2007, Radiother Oncol, 91, 15, 85-94(2009) DOI

Reference

10	(2013) International forum of allergy & rhinology Prognostic value of metabolic tumor volume as measured by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in nasopharyngeal carcinoma : Prognostic value of MTV by PET/C / 4 (10) , 845
4	(2014) European journal of nuclear medicine and molecular imaging Prognostic value of volumetric parameters measured by 18F-FDG PET/CT in patients with head and neck squamous cell carcinoma / 41 (4) , 659
1	(2013) Nuclear medicine and molecular imaging : NMMI Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology / 48 (1) , 1
4	(2014) Nuclear medicine and molecular imaging : NMMI Tumor SUVmax Normalized to Liver Uptake on 18F-FDG PET/CT Predicts the Pathologic Complete Response After Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer / 48 (4) , 295
6	(2013) The Journal of nuclear medicine : JNM Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis / 55 (6) , 884
1	(2013) Journal of thoracic imaging Positron Emission Tomography/Magnetic Resonance Imaging Evaluation of Lung Cancer: Current Status and Future Prospects / 29 (1) , 4
6	(2014) Yonsei medical journal Prognostic Significance of Volume-Based FDG PET/CT Parameters in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiation Therapy / 55 (6) , 1498
2	(2013) AJR : American journal of roentgenology FDG PET/CT for Management and Assessing Outcomes of Squamous Cell Cancer of the Oral Cavity / 205 (2) , W150
3	(2015) AJR : American journal of roentgenology Volume-Based Assessment With<SUP>18</SUP>F-FDG PET/CT Improves Outcome Prediction for Patients With Stage IIIA-N2 Non-Small Cell Lung Cancer / 205 (3) , 623
None	(2013) Frontiers in medicine State-Of-The-Art and Recent Advances in Quantification for Therapeutic Follow-Up in Oncology Using PET / 2 (None) , 18
4	(2015) La Radiologia medica Review of clinical practice utility of positron emission tomography with 18F-fluorodeoxyglucose in assessing tumour response to therapy / 120 (4) , 345
1	(2015) 頭頸部癌 The significance of pretreatment SUV (max) in the algorithm of &ldquo;chemoradioselection&rdquo; strategy for hypopharyngeal squamous cell carcinoma: a single-center experience / 41 (1) , 63
5	(2013) Abdominal imaging Comparison of 18F-FDG PET/CT methods of analysis for predicting response to neoadjuvant chemoradiation therapy in patients with locally advanced low rectal cancer / 40 (5) , 1190
2	(2013) Clinical and experimental otorhinolaryngology Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy / 8 (2) , 142
10	(2013) PLoS ONE Influence of Software Tool and Methodological Aspects of Total Metabolic Tumor Volume Calculation on Baseline [18F]FDG PET to Predict Survival in Hodgkin Lymphoma / 10 (10) , e0140830
2	(2016) European journal of nuclear medicine and molecular imaging The prognostic value of baseline 18F-FDG PET/CT in steroid-naïve large-vessel vasculitis: introduction of volume-based parameters / 43 (2) , 340
4	(2016) Annals of nuclear medicine Prognostic value of 18F-fluorodeoxyglucose positron emission tomography in patients with gastric neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma / 30 (4) , 279
8	(2016) Annals of nuclear medicine Functional volumetric analysis of striatum using F-18 FP-CIT PET in patients with idiopathic Parkinson’s disease and normal subjects / 30 (8) , 572
1	Ji Hyung Hong. (2013) Journal of Korean medical science : JKMS Total Lesion Glycolysis Using <SUP>18</SUP> F-FDG PET/CT as a Prognostic Factor for Locally Advanced Esophageal Cancer / 31 (1) , 39
1	(2016) Nuklearmedizin. Nuclear medicine Prognostic significance of volume-based 18F-FDG PET/CT parameter in patients with surgically resected non-small cell lung cancer : Comparison with immunohistochemical biomarkers / 55 (1) , 7
34	(2013) World journal of gastroenterology : WJG <SUP>18</SUP> F-fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma / 22 (34) , 7787
1	(2016) PLoS ONE Prognostic Value of <SUP>18</SUP> F-FDG PET/CT in Surgical Non-Small Cell Lung Cancer: A Meta-Analysis / 11 (1) , e0146195
5	(2016) Medicine The Highest Metabolic Activity on FDG PET Is Associated With Overall Survival in Limited-Stage Small-Cell Lung Cancer / 95 (5) , e2772
3	(2013) Annals of surgery Total 18F-FDG PET/CT Metabolic Tumor Volume Is Associated With Postoperative Biochemical Response in Patients With Metastatic Pheochromocytomas and Paragangliomas / 263 (3) , 582
suppl1	(2013) Head & neck Prognostic evaluation of percentage variation of metabolic tumor burden calculated by dual‐phase <SUP>18</SUP>FDG PET‐CT imaging in patients with head and neck cancer / 38 (suppl1) , E600
7	(2013) Journal of surgical oncology Prognostic significance of clinical and <SUP>18</SUP>F‐FDG PET/CT parameters for post‐distant metastasis survival in head and neck squamous cell carcinoma patients / 114 (7) , 888
3	(2013) Radiological physics and technology Verification of the tumor volume delineation method using a fixed threshold of peak standardized uptake value / 10 (3) , 311
4	(2017) Nutrition and cancer Risk of Malignancy in Thyroid Incidentaloma is Not Increased in Overweight or Obese Patients, but in Young Patients / 69 (4) , 580
33	(2017) Medicine Prognostic value of <SUP>18</SUP> F-FDG-PET/CT parameters in patients with pancreatic carcinoma : A systematic review and meta-analysis / 96 (33) , e7813
373	(2013) Science translational medicine Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma / 9 (373) , eaag2196
2	(2013) PLoS ONE Clinically determined type of <SUP>18</SUP> F-fluoro-2-deoxyglucose uptake as an alternative prognostic marker in resectable pancreatic cancer / 12 (2) , e0172606
17	(2013) Medicine Prognostic value of pretreatment <SUP>18</SUP> F-FDG PET-CT for nasopharyngeal carcinoma patients / 96 (17) , e6721
4	(2013) Journal of gynecologic oncology : jgo Prognostic value of metabolic parameters determined by preoperative <SUP>18</SUP> F-FDG PET/CT in patients with uterine carcinosarcoma / 28 (4) , e43
34	(2017) Medicine The clinical utility of splenic fluorodeoxyglucose uptake for diagnosis and prognosis in patients with macrophage activation syndrome / 96 (34) , e7901
2	(2018) Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association The prognostic value of volume-based parameters using 18F-FDG PET/CT in gastric cancer according to HER2 status / 21 (2) , 213
10	(2017) Journal of women's health Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point <SUP>18</SUP> F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma / 26 (10) , 1131
1	(2013) EJNMMI physics Comparison of novel multi-level Otsu (MO-PET) and conventional PET segmentation methods for measuring FDG metabolic tumor volume in patients with soft tissue sarcoma / 4 (1) , 22
12	(2013) The Journal of nuclear medicine : JNM Analysis of Prognostic Values of Various PET Metrics in Preoperative <SUP>18</SUP>F-FDG PET for Early-Stage Bronchial Carcinoma for Progression-Free and Overall Survival: Significantly Increased Glyco / 58 (12) , 1925
12	(2013) Nuclear medicine communications Meta-analysis of meta-analyses in oncologic positron emission tomography / 39 (12) , 1150
None	(2018) BMC medical imaging Prognostic value of metabolic tumor volume of pretreatment <SUP>18</SUP> F-FAMT PET/CT in non-small cell lung Cancer / 18 (None) , 46
5	(2013) AJR : American journal of roentgenology Prognostic Value of Volume-Based Metabolic Parameters of <SUP>18</SUP>F-FDG PET/CT in Uterine Cervical Cancer: A Systematic Review and Meta-Analysis / 211 (5) , 1112
4	(2013) Oncology letters Quantitative <SUP>18</SUP> F-FDG PET analysis in survival rate prediction of patients with non-small cell lung cancer / 16 (4) , 4129
12	(2018) Open journal of orthopedics Natural Postoperative Bone Metabolic Changes after Total Knee Arthroplasty Determined by Positron Emission Tomography Scans / 8 (12) , 443
1	(2013) Clinical nuclear medicine Role of Various Metabolic Parameters Derived From Baseline 18F-FDG PET/CT as Prognostic Markers in Non–Small Cell Lung Cancer Patients Undergoing Platinum-Based Chemotherapy / 43 (1) , e8
1	(2018) Nuclear medicine and molecular imaging : NMMI Current Methods to Define Metabolic Tumor Volume in Positron Emission Tomography: Which One is Better? / 52 (1) , 5
9	(2018) Acta radiologica Prognostic value of the maximum standardized uptake value of pre-treatment primary lesions in small-cell lung cancer on 18F-FDG PET/CT: a meta-analysis / 59 (9) , 1082
1	(2019) World journal of nuclear medicine Tumor volume delineation: A pilot study comparing a digital positron-emission tomography prototype with an analog positron-emission tomography system / 18 (1) , 45
None	(2013) Contrast media and molecular imaging Prediction of Overall Survival and Progression-Free Survival by the <SUP>18</SUP>F-FDG PET/CT Radiomic Features in Patients with Primary Gastric Diffuse Large B-Cell Lymphoma / 2019 (None) , 1
1	(2013) Nuclear medicine and molecular imaging : NMMI Radiomics in Oncological PET/CT: a Methodological Overview / 53 (1) , 14
None	(2013) Cancer imaging : the official publication of the International Cancer Imaging Society Metabolic tumor burden on postsurgical PET/CT predicts survival of patients with gastric cancer / 19 (None) , 18
6	(2013) Nuclear medicine and molecular imaging : NMMI Prognostic Value of Metabolic Information in Advanced Gastric Cancer Using Preoperative 18F-FDG PET/CT / 53 (6) , 386
1	(2013) Scientific reports Correlations between the metabolic profile and 18F-FDG-Positron Emission Tomography-Computed Tomography parameters reveal the complexity of the metabolic reprogramming within lung cancer patients / 9 (1) , 16212
1	(2013) BMC cancer Volumetric parameters on 18F-FDG PET/CT predict the survival of patients with gastric cancer associated with their expression status of c-MET / 19 (1) , 790
1	(2013) European radiology experimental Multiparametric quantitative and texture <SUP>18</SUP> F-FDG PET/CT analysis for primary malignant tumour grade differentiation / 3 (1) , 48
2	(2020) Oncology letters Predicting tumor recurrence using metabolic indices of <SUP>18</SUP> F-FDG PET/CT prior to orthotopic liver transplantationfor hepatocellular carcinoma / 20 (2) , 1245
3	(2013) Tumori : TJ Prognostic value of [<SUP>18</SUP>F]FDG PET/CT parameters in surgically resected primary lung adenocarcinoma: a single-center experience / 106 (3) , 212
6	(2013) Nuklearmedizin. Nuclear medicine 18F-FDG PET/CT imaging of vulva cancer recurrence: A comparison of PET-derived metabolic parameters between women with and without HIV infection / 59 (6) , 419
8	(2013) Clinical nuclear medicine Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Surgically Treated Stage I Lung Adenocarcinoma Patients / 46 (8) , 621
1	(2013) Journal of magnetic resonance imaging : JMRI PET/MRI in Cervical Cancer: Associations Between Imaging Biomarkers and Tumor Stage, Disease Progression, and Overall Survival / 53 (1) , 305
None	(2021) Contrast media and molecular imaging Prognostic Value of MTV and TLG of 18F-FDG PET in Patients with Stage I and II Non-Small-Cell Lung Cancer: a Meta-Analysis / 2021 (None) , 1
None	(2013) Frontiers in immunology Predictive Value of Metabolic Parameters Derived From 18F-FDG PET/CT for Microsatellite Instability in Patients With Colorectal Carcinoma / 12 (None) , 724464
4	(2021) Cancers Prognostic Significance of Metabolic Parameters by 18F-FDG PET/CT in Thymic Epithelial Tumors / 13 (4) , 712
2	(2013) Diagnostics Estimating the Potential of Radiomics Features and Radiomics Signature from Pretherapeutic PSMA-PET-CT Scans and Clinical Data for Prediction of Overall Survival When Treated with 177Lu-PSMA / 11 (2) , 186
None	(2013) Frontiers in oncology Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Panc / 11 (None) , 646141
None	(2013) Frontiers in oncology Evaluation of PD-L1 Expression Level in Patients With Non-Small Cell Lung Cancer by 18F-FDG PET/CT Radiomics and Clinicopathological Characteristics / 11 (None) , 789014
5	(2013) Cancer biotherapy & radiopharmaceuticals Role of Thyroglobulin Doubling Time in Differentiated Thyroid Cancer and Its Relationship with Demographic-Histopathologic Risk Factors and <SUP>18</SUP> F-Fluorodeoxyglucose Positron Emission Tomogr / 36 (5) , 425
1	(2013) BMC cancer Analysis of PET parameters as prognosticators of survival and tumor extent in Oropharyngeal Cancer treated with surgery and postoperative radiotherapy / 21 (1) , 317
12	(2021) Metabolites Prognostic Value of Pretherapeutic Primary Tumor MTV from [18F]FDG PET in Radically Treated Cervical Cancer Patients / 11 (12) , 809