Browse > Article
http://dx.doi.org/10.3348/kjr.2012.13.1.94

Pancreatic Islet Cell Amyloidosis Manifesting as a Large Pancreas  

Onur, Mehmet Ruhi (Department of Radiology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu)
Yalniz, Mehmet (Department of Gastroenterology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu)
Poyraz, Ahmet Kursad (Department of Radiology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu)
Ozercan, Ibrahim Hanifi (Department of Pathology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu)
Ozkan, Yusuf (Department of Endocrinology, University of Firat, Faculty of Medicine, Firat Universitesi Hastanesi Rektorluk Kampusu)
Publication Information
Korean Journal of Radiology / v.13, no.1, 2012 , pp. 94-97 More about this Journal
Abstract
A 39-year-old female patient presented to our hospital with epigastric pain lasting for two months. Laboratory results showed impaired glucose tolerance. Ultrasonography of the patient showed a hypoechoic, diffusely enlarged pancreas. CT revealed a large pancreas, with multiple calcifications. On MRI, a diffusely enlarged pancreas was seen hypointense on both T1- and T2-weighted images with heterogeneous enhancement after gadolinium administration. A biopsy of the pancreas revealed primary amyloidosis of islet cells. Decreased signal on T1-weighted images without inflammation findings on CT and MRI were clues for the diagnosis.
Keywords
Pancreas; Amyloidosis; Ultrasonography; Computed tomography; Magnetic resonance imaging;
Citations & Related Records
 (Related Records In Web of Science)
Times Cited By SCOPUS : 3
연도 인용수 순위
  • Reference
1 De Backer AI, Mortele KJ, Bomans P, De Keulenaer BL, Vanschoubroeck IJ, Kockx MM. Tuberculosis of the pancreas: MRI features. AJR Am J Roentgenol 2005;184:50-54   DOI   ScienceOn
2 Hoppener JW, Nieuwenhuis MG, Vroom TM, Ahren B, Lips CJ. Role of islet amyloid in type 2 diabetes mellitus: consequence or cause? Mol Cell Endocrinol 2002;197:205-212   DOI   ScienceOn
3 Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med 1997;337:898-909   DOI   ScienceOn
4 Georgiades CS, Neyman EG, Barish MA, Fishman EK. Amyloidosis: review and CT manifestations. Radiographics 2004;24:405-416   DOI   ScienceOn
5 Urban BA, Fishman EK, Goldman SM, Scott WW Jr, Jones B, Humphrey RL, et al. CT evaluation of amyloidosis: spectrum of disease. Radiographics 1993;13:1295-1308   DOI
6 Ozdemir D, Dagdelen S, Erbas T. Endocrine involvement in systemic amyloidosis. Endocr Pract 2010;16:1056-1063   DOI   ScienceOn
7 Garcia RL. Verrucose areolar hyperpigmentation of pregnancy. Arch Dermatol 1973;107:774   DOI
8 Kennan NM, Evans C. Case report: hepatic and splenic calcification due to amyloid. Clin Radiol 1991;44:60-61   DOI   ScienceOn
9 Sainani N, Catalano O, Sahani D. Pancreas. In: Haaga JR, Dogra VS, Forsting M, Gilkeson RC, Ha HK, Sundaram M, eds. CT and MRI of the whole body. Philadelphia: Mosby Elsevier, 2009:1599-1675
10 Rafal RB, Jennis R, Kosovsky PA, Markisz JA. MRI of primary amyloidosis. Gastrointest Radiol 1990;15:199-201   DOI   ScienceOn