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http://dx.doi.org/10.3348/kjr.2011.12.5.579

Radiofrequency Ablation for Treating Liver Metastases from a Non-Colorectal Origin  

Yun, Bo-La (Department of Radiology, Seoul National University Hospital)
Lee, Jeong-Min (Department of Radiology, Seoul National University Hospital)
Baek, Ji-Hyun (Department of Radiology, Seoul National University Hospital)
Kim, Se-Hyung (Department of Radiology, Seoul National University Hospital)
Lee, Jae-Young (Department of Radiology, Seoul National University Hospital)
Han, Joon-Koo (Department of Radiology, Seoul National University Hospital)
Choi, Byung-Ihn (Department of Radiology, Seoul National University Hospital)
Publication Information
Korean Journal of Radiology / v.12, no.5, 2011 , pp. 579-587 More about this Journal
Abstract
Objective: We wanted to assess the safety and efficacy of performing radiofrequency ablation (RFA) in patients with noncolorectal liver metastases. Materials and Methods: In this retrospective study, 25 patients with 40 hepatic metastases (M:F = 17:8; mean age, 57 years; tumor size, 0.5-5.0 cm) from a non-colorectal origin (stomach, biliary, breast, pancreas, kidney and skin) were treated with RFA. The RFA procedures were performed using either an internally cooled electrode or a clustered electrode under ultrasound or CT guidance. Contrast-enhanced CT scans were obtained immediately after RFA and follow-up CT scans were performed within three months after ablation and subsequently at least every six months. The intrahepatic diseasefree interval was estimated and the overall survival from the time of the initial RFA was analyzed using the Kaplan-Meier method. Results: No intraprocedural deaths occurred, but four major complications developed, including abscesses (n = 3) and pneumothorax (n = 1). Technical effectiveness was determined on the initial follow-up images. During the follow-up period (range, 5.9-68.6 months; median time, 18.8 months) for 37 tumors in 22 patients where technical effectiveness was achieved, 12 lesions (32%, 12 of 37) showed local tumor progression and new intrahepatic metastases occurred in 13 patients (59%, 13 of 22). The median intrahepatic disease-free interval was 10.1 months. The 1-year, 3-year and 5-year overall survival rates after RFA were 86%, 39% and 19%, respectively. Conclusion: RFA showed intermediate therapeutic effectiveness for the treatment of non-colorectal origin liver metastases.
Keywords
Liver; Interventional procedures; Radiofrequency ablation; Preliminary clinical study;
Citations & Related Records
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