Effects of Propranolol on the Left Ventricular Volume of Normal Subjects During CT Coronary Angiography

Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/$m^2$, 6.1 to 57.1 mL/$m^2$ and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ${\pm}$ 17 and 80 ${\pm}$ 10 mmHg; 120 ${\pm}$ 14 and 80 ${\pm}$ 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real- EF showed significant differences between these two groups (69.4 ${\pm}$ 9.3 and 70.6 ${\pm}$ 8.9 mL/$m^2$ 23.5 ${\pm}$ 5.7 and 25.6 ${\pm}$ 3.7 mL/$m^2$, 66.5 ${\pm}$ 5.1% and 63.5 ${\pm}$ 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.