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http://dx.doi.org/10.3348/kjr.2011.12.3.269

Liver Flukes: the Malady Neglected  

Lim, Jae-Hoon (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Korean Journal of Radiology / v.12, no.3, 2011 , pp. 269-279 More about this Journal
Abstract
Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause human infection are Clonorchis sinensis, Opisthorchis viverrini and Opisthorchis felineus. Adult flukes settle in the small intrahepatic bile ducts and then they live there for 20-30 years. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. The vast majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. The complications are stone formation, recurrent pyogenic cholangitis and cholangiocarcinoma. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the impact of this food-borne malady on public health and the severe possible clinical consequences, liver fluke infection should not be forgotten or neglected.
Keywords
Liver flukes; Clonorchiasis; Opisthorchiasis; Cholangiocarcinoma; Foodborne parasite; Cholangiocarinogenesis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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1 Control of foodborne trematode infections. Report of a WHO Study Group. World Health Organ Tech Rep Ser 1995;849:1-157
2 Rim HJ, Kim KH, Joo KH. Classification and host specificity of Metagonimus spp. from Korean freshwater fish. Korean J Parasitol 1996;34:7-14   DOI   ScienceOn
3 Rim HJ. Clonorchiasis: an update. J Helminthol 2005;79:269-281   DOI   ScienceOn
4 Jongsuksuntigul P, Imsomboon T, Teerarat S, Suruthanavanith P, Kongpradit S. Consequences of opisthorchiasis control programme in northeastern Thailand. J Trop Med Parasitol 1996;19:24-39
5 Lim JH. Radiologic findings of clonorchiasis. AJR Am J Roentgenol 1990;155:1001-1008   DOI   ScienceOn
6 Riganti M, Pungpak S, Punpoowong B, Bunnag D, Harinasuta T. Human pathology of Opisthorchis viverrini infection: a comparison of adults and children. Southeast Asian J Trop Med Public Health 1989;20:95-100
7 Sripa B. Pathobiology of opisthorchiasis: an update. Acta Trop 2003;88:209-220   DOI   ScienceOn
8 Mairiang E, Mairiang P. Clinical manifestation of opisthorchiasis and treatment. Acta Trop 2003;88:221-227   DOI   ScienceOn
9 Harinasuta T, Riganti M, Bunnag D. Opisthorchis viverrini infection: pathogenesis and clinical features. Arzneimittelforschung 1984;34:1167-1169
10 Upatham ES, Viyanant V, Kurathong S, Rojborwonwitaya J, Brockelman WY, Ardsungnoen S, et al. Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in north-east Thailand. Bull World Health Organ 1984;62:451-461
11 Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB, et al. Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis 2005;5:31-41   DOI   ScienceOn
12 Coordinating Office of the National Survey on the Important Human Parasitic Diseases. A national survey on current status of the important parasitic diseases in human population. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2005;23:332-340
13 Jongsuksuntigul P, Imsomboon T. Epidemiology of opisthorchiasis and national control program in Thailand. Southeast Asian J Trop Med Public Health 1998;29:327-332
14 Kaewpitoon N, Kaewpitoon SJ, Pengsaa P. Opisthorchiasis in Thailand: review and current status. World J Gastroenterol 2008;14:2297-2302   DOI   ScienceOn
15 Upatham ES, Viyanant V, Kurathong S, Brockelman WY, Menaruchi A, Saowakontha S, et al. Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. Am J Trop Med Hyg 1982;31:1156-1163   DOI
16 Prevalence of intestinal parasitic infection in Korea, the 7th Report: Korea Association of Health Promotion, 2004:122-123
17 Choi D, Lim JH, Lee KT, Lee JK, Choi SH, Heo JS, et al. Cholangiocarcinoma and Clonorchis sinensis infection: a casecontrol study in Korea. J Hepatol 2006;44:1066-1073   DOI   ScienceOn
18 Flavell DJ. Liver-fluke infection as an aetiological factor in bile-duct carcinoma of man. Trans R Soc Trop Med Hyg 1981;75:814-824   DOI   ScienceOn
19 Pae WK. Bacteriological and parasitological study of stone. J Korean Surg Soc 1968;10:377-380
20 Joo KR, Bang SJ. A bile based study of Clonorchis sinensis infections in patients with biliary tract diseases in Ulsan, Korea. Yonsei Med J 2005;46:794-798   DOI   ScienceOn
21 Choi D, Lim JH, Lee KT, Lee JK, Choi SH, Heo JS, et al. Gallstones and Clonorchis sinensis infection: a hospitalbased case-control study in Korea. J Gastroenterol Hepatol 2008;23:e399-404   DOI   ScienceOn
22 Wong WT, Teoh-Chan CH, Huang CT, Cheng FC, Ong GB. The bacteriology of recurrent pyogenic cholangitis and associated diseases. J Hyg (Lond) 1981;87:407-412   DOI
23 Nakanuma Y, Sripa B, Vantanasapt V, Leong A-Y, Ponchon T, Ishak KG. Intrahepatic cholangiocarcinoma. In: Hamilton SR, Aaltonen LA, eds. World Health Organization classification of tumors. Pathology and genetics of tumours of the digestive system. Lyon, France: IARC Press, 2000:173-180
24 Jung KW, Won YJ, Park S, Kong HJ, Sung J, Shin HR, et al. Cancer statistics in Korea: incidence, mortality and survival in 2005. J Korean Med Sci 2009;24:995-1003   DOI   ScienceOn
25 Bhamarapravati N, Virranuvatti V. Liver diseases in Thailand. An analysis of liver biopsies. Am J Gastroenterol 1966;45:267-275
26 Watanapa P, Watanapa WB. Liver fluke-associated cholangiocarcinoma. Br J Surg 2002;89:962-970   DOI   ScienceOn
27 Haswell-Elkins MR, Satarug S, Tsuda M, Mairiang E, Esumi H, Sithithaworn P, et al. Liver fluke infection and cholangiocarcinoma: model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis. Mutat Res 1994;305:241-252   DOI   ScienceOn
28 Elkins DB, Mairiang E, Sithithaworn P, Mairiang P, Chaiyakum J, Chamadol N, et al. Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans. Am J Trop Med Hyg 1996;55:295-301   DOI
29 Haswell-Elkins MR, Mairiang E, Mairiang P, Chaiyakum J, Chamadol N, Loapaiboon V, et al. Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int J Cancer 1994;59:505-509   DOI   ScienceOn
30 Sithithaworn P, Haswell-Elkins MR, Mairiang P, Satarug S, Mairiang E, Vatanasapt V, et al. Parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast Thailand. Int J Parasitol 1994;24:833-843   DOI   ScienceOn
31 Kurathong S, Lerdverasirikul P, Wongpaitoon V, Pramoolsinsap C, Kanjanapitak A, Varavithya W, et al. Opisthorchis viverrini infection and cholangiocarcinoma. A prospective, casecontrolled study. Gastroenterology 1985;89:151-156   DOI
32 Elkins DB, Haswell-Elkins MR, Mairiang E, Mairiang P, Sithithaworn P, Kaewkes S, et al. A high frequency of hepatobiliary disease and suspected cholangiocarcinoma associated with heavy Opisthorchis viverrini infection in a small community in north-east Thailand. Trans R Soc Trop Med Hyg 1990;84:715-719   DOI   ScienceOn
33 Chung CS, Lee SK. An epidemiological study of primary liver carcinomas in Pusan area with special reference to clonorchiasis. Korean J Pathol 1976;10:33-46
34 Shin HR, Lee CU, Park HJ, Seol SY, Chung JM, Choi HC, et al. Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea. Int J Epidemiol 1996;25:933-940   DOI   ScienceOn
35 Suh KS, Roh HR, Koh YT, Lee KU, Park YH, Kim SW. Clinicopathologic features of the intraductal growth type of peripheral cholangiocarcinoma. Hepatology 2000;31:12-17   DOI   ScienceOn
36 Jang KT, Hong SM, Lee KT, Lee JG, Choi SH, Heo JS, et al. Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection. Virchows Arch 2008;453:589-598   DOI   ScienceOn
37 Hou PC. The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol 1956;72:239-246   DOI
38 Kim YI. Liver carcinoma and liver fluke infection. Arzneimittelforschung 1984;34:1121-1126
39 Sherr CJ. Cancer cell cycles. Science 1996;274:1672-1677   DOI   ScienceOn
40 Zen Y, Sasaki M, Fujii T, Chen TC, Chen MF, Yeh TS, et al. Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis. J Hepatol 2006;44:350-358   DOI   ScienceOn
41 Shimonishi T, Sasaki M, Nakanuma Y. Precancerous lesions of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 2000;7:542-550   DOI   ScienceOn
42 Chen TC, Nakanuma Y, Zen Y, Chen MF, Jan YY, Yeh TS, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology 2001;34:651-658
43 Nakanuma Y, Sasaki M, Ishikawa A, Tsui W, Chen TC, Huang SF. Biliary papillary neoplasm of the liver. Histol Histopathol 2002;17:851-861
44 Shimonishi T, Zen Y, Chen TC, Chen MF, Jan YY, Yeh TS, et al. Increasing expression of gastrointestinal phenotypes and p53 along with histologic progression of intraductal papillary neoplasia of the liver. Hum Pathol 2002;33:503-511   DOI   ScienceOn
45 Lee JH, Yang HM, Bak UB, Rim HJ. Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis. Korean J Parasitol 1994;32:13-18   DOI   ScienceOn
46 Lee JH, Rim HJ, Bak UB. Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters. Korean J Parasitol 1993;31:21-30   DOI   ScienceOn
47 Satarug S, Haswell-Elkins MR, Sithithaworn P, Bartsch H, Ohshima H, Tsuda M, et al. Relationships between the synthesis of N-nitrosodimethylamine and immune responses to chronic infection with the carcinogenic parasite, Opisthorchis viverrini, in men. Carcinogenesis 1998;19:485-491   DOI   ScienceOn
48 Thamavit W, Pairojkul C, Tiwawech D, Shirai T, Ito N. Strong promoting effect of Opisthorchis viverrini infection on dimethylnitrosamine-initiated hamster liver. Cancer Lett 1994;78:121-125   DOI   ScienceOn
49 Levy C, Lymp J, Angulo P, Gores GJ, Larusso N, Lindor KD. The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis. Dig Dis Sci 2005;50:1734-1740   DOI   ScienceOn
50 Patel AH, Harnois DM, Klee GG, LaRusso NF, Gores GJ. The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis. Am J Gastroenterol 2000;95:204-207   DOI   ScienceOn
51 John AR, Haghighi KS, Taniere P, Esmat ME, Tan YM, Bramhall SR. Is a raised CA 19-9 level diagnostic for a cholangiocarcinoma in patients with no history of sclerosing cholangitis? Dig Surg 2006;23:319-324   DOI   ScienceOn
52 Nehls O, Gregor M, Klump B. Serum and bile markers for cholangiocarcinoma. Semin Liver Dis 2004;24:139-154   DOI   ScienceOn