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http://dx.doi.org/10.3348/kjr.2010.11.2.244

Assessing a Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease) with 7T MR Imaging  

Moenninghoff, Christoph (Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen)
Kraff, Oliver (Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen)
Schlamann, Marc (Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen)
Ladd, Mark E. (Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen)
Katsarava, Zaza (Department of Neurology, University Hospital Essen)
Gizewski, Elke R. (Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen)
Publication Information
Korean Journal of Radiology / v.11, no.2, 2010 , pp. 244-248 More about this Journal
Abstract
Lhermitte-Duclos disease (LDD; dysplastic cerebellar gangliocytoma) is a rare hamartomatous lesion of the cerebellar cortex and this was first described in 1920. LDD is considered to be part of the autosomal-dominant phacomatosis and cancer syndrome Cowden disease (CS). We examined the brain of a 46-year-old man, who displayed the manifestations of CS, with 7 Tesla (T) and 1.5T MRI and 1.5T MR spectroscopy ($^1H$-MRS). We discuss the possible benefits of employing ultrahigh-field MRI for making the diagnosis of this rare lesion.
Keywords
Lhermitte-Duclos disease; 7 Tesla; Magnetic resonance (MR); Dysplastic cerebellar gangliocytoma; Susceptibility-weighted imaging;
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 8
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1 Padberg GW, Schot JD, Vielvoye GJ, Bots GT, de Beer FC. Lhermitte-Duclos disease and Cowden disease: a single phakomatosis. Ann Neurol 1991;29:517-523   DOI   ScienceOn
2 Carter JE, Merren MD, Swann KW. Preoperative diagnosis of Lhermitte-Duclos disease by magnetic resonance imaging. Case report. J Neurosurg 1989;70:135-137   DOI
3 Kulkantrakorn K, Awwad EE, Levy B, Selhorst JB, Cole HO, Leake D, et al. MRI in Lhermitte-Duclos disease. Neurology 1997;48:725-731   DOI   ScienceOn
4 Nagaraja S, Powell T, Griffiths PD, Wilkinson ID. MR imaging and spectroscopy in Lhermitte-Duclos disease. Neuroradiology 2004;46:355-358   DOI   ScienceOn
5 Wolansky LJ, Malantic GP, Heary R, Maniker AH, Lee HJ, Sharer LR, et al. Preoperative MRI diagnosis of Lhermitte-Duclos disease: case report with associated enlarged vessel and syrinx. Surg Neurol 1996;45:470-475   DOI   ScienceOn
6 Thomas B, Krishnamoorthy T, Radhakrishnan VV, Kesavadas C. Advanced MR imaging in Lhermitte-Duclos disease: moving closer to pathology and pathophysiology. Neuroradiology 2007;49:733-738   DOI   ScienceOn
7 Meltzer CC, Smirniotopoulos JG, Jones RV. The striated cerebellum: an MR imaging sign in Lhermitte-Duclos disease (dysplastic gangliocytoma). Radiology 1995;194:699-703   DOI
8 Ambler M, Pogacar S, Sidman R. Lhermitte-Duclos disease (granule cell hypertrophy of the cerebellum) pathological analysis of the first familial cases. J Neuropathol Exp Neurol 1969;28:622-647   DOI
9 Klisch J, Juengling F, Spreer J, Koch D, Thiel T, Buchert M, et al. Lhermitte-Duclos disease: assessment with MR imaging, positron emission tomography, single-photon emission CT, and MR spectroscopy. AJNR Am J Neuroradiol 2001;22:824-830
10 Lhermitte J, Duclos P. Sur un ganglioneurome diffuse du cortex du cervelet. Bulletin de l' Association francaise pour l' etude du cancer. Paris 1920;9:99-107