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http://dx.doi.org/10.3348/kjr.2004.5.1.19

Usefulness of Multidetector-row CT in the Evaluation of Reperfused Myocardial Infarction in a Rabbit Model  

Park, Jong-Min (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choe, Yeon-Hyeon (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Chang, Samuel (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Sung, Yon-Mi (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kang, Seok-Seon (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kim, Min-Joo (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Han, Boo-Kyung (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choi, Sang-Hee (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Korean Journal of Radiology / v.5, no.1, 2004 , pp. 19-24 More about this Journal
Abstract
Objective: To evaluate the usefulness of multidetector-row computed tomography (CT) in the evaluation of reperfused myocardial infarction. Materials and Methods: Eleven rabbits were subjected to 90-min occlusion of the left anterior descending coronary artery followed by reperfusion. Multidetector-row CT was performed 31 hours ${\pm}$ 21 after the procedure and preand post-contrast multiphase helical CT images were obtained up to 10 min after contrast injection. The animals were sacrificed after 30 days and histochemical staining of the resected specimens was perfomed with 2'3'5-triphenyl tetrazolium chloride (TTC). Results: In all 11 cases, the areas of myocardial infarction demonstrated with TTC-staining were identified on the CT images and the lesions showed hypoenhancement on the early phases up to 62 sec and hyperenhancement on the delayed phases of 5 min and 10 min compared with normal myocardial enhancement. The percentage area of the lesion with respect to the left ventricle wall on CT was significantly correlated with that of the TTC-staining results ($\rho$< 0.001 for both early and delayed phase CT) according to the generalized linear model analysis. The areas showing hypoenhancement on early CT were significantly smaller than those with hyperenhancement on delayed CT ($\rho$ < 0.0001). Conclusion: Multidetector-row CT may be useful in the detection and sizing of reperfused myocardial infarction.
Keywords
Animals; Computed tomography (CT), multidetector-row; Computed tomography (CT), helical technology; Myocardium, infarction; Myocardium, CT; Heart, CT;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 23  (Related Records In Web of Science)
Times Cited By SCOPUS : 23
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1 McNarama MT,Tscholakoff D,Revel D,et al. Differentiation of reversible and irreversible myocardial injury by MR imaging with and without gadolinium-DTPA. Radiology 1986;158:765–769.
2 Pereira RS,Prato FS,Wisenberg G,Sykes J. The determination of myocardial viability using Gd-DTPA in a canine model of acute myocardial ischemia and reperfusion. Magn Reson Med 1996;36:684–693.
3 Higgins CB,Siemers PT,Schmidt W,et al. Evaluation of myocardial ischemic damage of various ages by computerized transmission tomography. Time-dependent effects of contrast material. Circulation 1979;60:284–291.
4 Wesbey G,Higgins CB,Lanzer P,Botvinick E,Lipton MJ. Imaging and characterization of acute myocardial infarction in vivo by gated nuclear magnetic resonance. Circulation 1984;69:125–130.
5 Ratner RV,Okada RD,Newell JB,Pohost GM. The relationship between proton nuclear magnetic resonance relaxation parameters and myocardial perfusion with acute coronary arterial occlusion and reperfusion. Circulation 1985;71:823–828.
6 McNamara MT,Tscholakoff D,Revel D,et al. Differentiation of reversible and irreversible myocardial injury by MR imaging with and without gadolinium-DTPA. Radiology 1986;158:765–769.
7 Peshock RM,Malloy CR,Buja LM,Nunnally RL,Parkey RW,Willerson JT. Magnetic resonance imaging of acute myocardial infarction: gadolinium diethylenetriamine pentaacetic acid as a marker of reperfusion. Circulation 1986;74:1434–1440.
8 Saeed M,Lund G,Wendland MF,Bremerich J,Weinmann H,Higgins CB. Magnetic resonance characterization of the periinfarction zone of reperfused myocardial infarction with necrosis-specific and extracellular nonspecific contrast media. Circulation 2001;103:871–876.
9 Kuijper AF,Vliegen HW,van der Wall EE,et al. The clinical impact of thallium-201 reinjection scintigraphy for detection of myocardial viability. Eur J Nucl Med 1992;19:783–789.
10 Hilfiker PR,Weishaupt D,Marincek B. Multislice spiral computed tomography of subacute myocardial infarction. Circulation 2001;104:1083.
11 Arheden H,Saeed M,Higgins CB,et al. Reperfused rat myocardium subjected to various durations of ischemia: estimation of the distribution volume of contrast material with echo-planar MR imaging. Radiology 2000;215:520–528.
12 Gray WR Jr,Parkey RW,Buja LM,et al. Computed tomography: in vitro evaluation of myocardial infarction. Radiology 1977;122:511–513.
13 Phelps ME,Hoffman EJ,Selin C,et al. Investigation of [18F]2-deoxyglucose for the measure of myocardial glucose metabolism. J Nucl Med 1978;19:1311–1319.
14 Rogers WJ Jr,Kramer CM,Geskin G,et al. Early contrast-enhanced MRI predicts late functional recovery after reperfused myocardial infarction. Circulation 1999;99:744–750.
15 Willmann JK,Szente-Varga M,Roos JE,Hilfiker PR,Weishaupt D. Three-dimensional images of extra-anatomic arterial bypass graft using multidetector row spiral computed tomography data with volume rendering. Circulation 2001;104:E154–E155.
16 Williams MJ,Odabashian J,Lauer MS,Thomas JD,Marwick TH. Prognostic value of dobutamine echocardiography in patients with left ventricular dysfunction. J Am Coll Cardiol 1996;27:132–139.
17 Choi SI,Jiang CZ,Lim KH,et al. Application of breath-hold T2-weighted, first-pass perfusion and gadolinium-enhanced T1-weighted MR imaging for assessment of myocardial viability in a pig model. J Magn Reson Imaging 2000;11:476–480.
18 Saeed M,Wendland MF,Takehara Y,Higgins CB. Reversible and irreversible injury in the reperfused myocardium: differentiation with contrast material-enhanced MR imaging. Radiology 1990;175:633–637.
19 Tscholakoff D,Higgins CB,Sechtem U,McNamara MT. Occlusive and reperfused myocardial infarcts: effects of Gd-DTPA on ECG-gated MR imaging. Radiology 1986;160:515–519.
20 Burt RW,Perkins OW,Oppenheim BE,et al. Direct comparison of fluorine-18-FDG SPECT, fluorine-18-FDG PET and rest thallium-201 SPECT for detection of myocardial viability. J Nucl Med 1995;36:176–179.
21 Wesbey GE,Higgins CB,McNarama MT,et al. Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium. Radiology 1984;153:165–169.
22 Budoff MJ,Achenbach S,Duerinckx A. Clinical utility of computed tomography and magnetic resonance techniques for noninvasive coronary angiography. J Am Coll Cardiol 2003;42:1867–1878.
23 Saeed M,Bremerich J,Wendland MF,Wyttenbach R,Weinmann HJ,Higgins CB. Reperfused myocardial infarction as seen with use of necrosis-specific versus standard extracellular MR contrast media in rats. Radiology 1999;213:247–257.
24 McNamara MT,Higgins CB,Ehman RL,Revel D,Sievers R,Brasch RC. Acute myocardial ischemia: magnetic resonance contrast enhancement with gadolinium-DTPA. Radiology 1984;153:157–163.
25 Kim RJ,Fieno DS,Parrish TB,et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999;100:1992–2002.
26 Hessel SJ,Adams DF,Judy PF,Fishbein MC,Abrams HL. Detection of myocardial ischemia in vitro by computed tomography. Radiology 1978;127:413–418.
27 Tscholakoff D,Higgins CB,McNamara MT,Derugin N. Early-phase myocardial infarction: evaluation by MR imaging. Radiology 1986;159:667–672.
28 Fishbein MC,Meerbaum S,Rit J,et al. Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique. Am Heart J 1981;101:593–600.
29 Mochizuki T,Murase K,Higashino H,Koyama Y,Azemoto S,Ikezoe J. Demonstration of acute myocardial infarction by subsecond spiral computed tomography: early defect and delayed enhancement. Circulation 1999;99:2058–2059.
30 Sicari R,Picano E,Landi P,et al. Prognostic value of dobutamine-atropine stress echocardiography early after acute myocardial infarction. Echo Dobutamine International Cooperative (EDIC) Study. J Am Coll Cardiol 1997;29:254–260.
31 Cipriano PR,Nassi M,Ricci MT,Reitz BA,Brody WR. Acute myocardial ischemia detected in vivo by computed tomography. Radiology 1981;140:727–731.
32 Schaefer S,Malloy CR,Katz J,et al. Gadolinium-DTPA-enhanced nuclear magnetic resonance imaging of reperfused myocardium: identification of the myocardial bed at risk. J Am Coll Cardiol 1988;12:1064–1072.