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Glucose-lowering Effect of Powder Formulation of African Black Tea Extract in $KK-A^y/TaJcl$ Diabetic Mouse  

Shoji, Yoko (Department of Microbiology, St. Marianna University School of Medicine)
Nakashima, Hideki (Department of Microbiology, St. Marianna University School of Medicine)
Publication Information
Archives of Pharmacal Research / v.29, no.9, 2006 , pp. 786-794 More about this Journal
Abstract
We observed the suppressive effect of a powder formulation of African black tea extract prepared from the leaves of Camellia sinensis on type 2 non-insulin dependent diabetic mice, $KK-A^y/TaJcl$. Black tea extract significantly showed suppressive effect of the elevation of blood glucose on oral glucose tolerance test of 8 week-old $KK-A^y/TaJcl$ mice (p<0.05). Long-term treatment with black tea extract showed significant suppression of post-prandial blood glucose and obesity (p<0.05). The weight of the intestine of mice treated with black tea extract was significantly reduced (p<0.05). From these results, African black tea used in this study showed a suppressive effect on the elevation of blood glucose during food intake and the body weight.
Keywords
Black tea extract; Glucose-lowering; Theaflavin; Tea polyphenol; Adipocyte;
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