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Antifungal Effect of Amentoflavone derived from Selaginella tamariscina  

Jung, Hyun-Jun (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Sung, Woo-Sang (Department of Microbiology, College of Natural Sciences, Kyungpook National University,Agro-Biotechnology Education Center, Kyungpook National University)
Yeo, Soo-Hwan (The Center for Traditional Microorganism Resources (TMR), Keimyung University)
Kim, Hyun-Soo (The Center for Traditional Microorganism Resources (TMR), Keimyung University)
Lee, In-Seon (The Center for Traditional Microorganism Resources (TMR), Keimyung University)
Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Lee, Dong-Gun (Department of Microbiology, College of Natural Sciences, Kyungpook National University)
Publication Information
Archives of Pharmacal Research / v.29, no.9, 2006 , pp. 746-751 More about this Journal
Abstract
Amentoflavone is a plant biflavonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very low hemolytic effect on human erythrocytes. In particular, amentoflavone induced the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae during pathogenesis. In conclusion, amentoflavone has great potential to be a lead compound for the development of antifungal agents.
Keywords
Biflavonoid; Amentoflavone; Antifungal activity; Dimorphic transition;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 9  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
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