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Inhibitory Effect of Ginsenoside Rg5 and Its Metabolite Ginsenoside Rh3 in an Oxazolone-Induced Mouse Chronic Dermatitis Model  

Shin, Yong-Wook (College of Pharmacy, Kyung Hee University)
Bae, Eun-Ah (College of Pharmacy, Kyung Hee University)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Archives of Pharmacal Research / v.29, no.8, 2006 , pp. 685-690 More about this Journal
Abstract
The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin $(IL)-1{\beta}$, tumor necrosis factor $(TNF)-{\alpha}$ and interferon $(IFN)-{\gamma}$. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of $IL-1{\beta}$ and $TNF-{\alpha}$ produced by macrophage cells and of $IFN-{\gamma}$ produced by Th cells.
Keywords
Ginsenoside Rg5; Ginsenoside Rh3; COX-2; $IFN-{\gamma}$; Psoriasis;
Citations & Related Records

Times Cited By Web Of Science : 15  (Related Records In Web of Science)
Times Cited By SCOPUS : 11
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