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Retarded Dissolution of Ibuprofen in Gelatin Microcapsule by Cross-Linking with Glutaradehyde  

Yong, Chul-Soon (College of Pharmacy, Yeungnam University)
Li, Dong-Xun (College of Pharmacy, Yeungnam University)
Oh, Dong-Hoon (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University)
Woo, Jong-Soo (College of Pharmacy, Yeungnam University)
Rhee, Jong-Dal (College of Pharmacy, Yeungnam University)
Choi, Han-Gon (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.29, no.6, 2006 , pp. 520-524 More about this Journal
Abstract
Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded crosslinked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.
Keywords
Ibuprofen; Cross-linked gelatin microcapsule; Glutaraldehyde; Dissolution;
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