Retarded Dissolution of Ibuprofen in Gelatin Microcapsule by Cross-Linking with Glutaradehyde
![]() ![]() |
Yong, Chul-Soon
(College of Pharmacy, Yeungnam University)
Li, Dong-Xun (College of Pharmacy, Yeungnam University) Oh, Dong-Hoon (College of Pharmacy, Yeungnam University) Kim, Jung-Ae (College of Pharmacy, Yeungnam University) Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University) Woo, Jong-Soo (College of Pharmacy, Yeungnam University) Rhee, Jong-Dal (College of Pharmacy, Yeungnam University) Choi, Han-Gon (College of Pharmacy, Yeungnam University) |
1 | Ganguly, S. and Dash, A. K., A novel in situ gel for sustained drug delivery and targeting. Int. J. Pharm., 276, 83-92 (2004) DOI ScienceOn |
2 | Glowka, F.K., Stereoselective Pharmacokinetics of ibuprofen and its lysinate from suppositories in rabbits. Int. J. Pharm., 199, 159-166 (2000) DOI ScienceOn |
3 | Kim, T. K. and Burgess, D. J., Formulation and release characteristics of poly(lactic-co-glycolic acid) microspheres containing chemically modified protein. J. Pharm. Pharmacol., 2001 53, 23-31 (2001) DOI ScienceOn |
4 | Yong, C. S., Oh, Y. K., Jung, S. H., Rhee, J. D., Kim, H. D., Kim, C. K., Choi, J. S., and Choi, H. G., Preparation of ibuprofenloaded liquid suppository using eutectic mixture system with menthol. Eur. J. Pharm. Sci., 23, 347-353 (2004) DOI ScienceOn |
5 | Greenhalgh, D.J., Williams, A.C., Timmins, P., and York, P., Solubility parameters as predictors of miscibility in solid dispersions. J. Pharm. Sci., 88, 1182-1190 (1999) DOI |
6 | Tabata, Y. and Ikada, Y., Synthesis of gelatin microspheres containing interferon. Pharm. Res., 6, 422-427 (1989) DOI |
7 | Kim, C. K., Choi, J. Y., Yoon, Y. S., Gong, J. P., Choi, H. G., Kong, J. Y., and Lee, B. J., Preparation and evaluation of dry elixir for the enhancement of dissolution rate of poorly watersoluble drugs. Int. J. Pharm., 106, 25-32 (1997) DOI ScienceOn |
8 | Khan, G. M. and Jiabi, Z., Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers. Drug Dev. Ind. Pharm., 24, 455-462 (1998) DOI |
9 | Ahn, H. J., Kim, K. M., and Kim, C. K., Enhancement of bioavailability of ketoprofen using drug elixir as a novel dosage form. Drug Dev. Ind. Pharm., 24, 697-701 (1998) DOI |
10 | Akbuga, J. and Bergisadi, N., Effect of formulation variables on cis-platin loaded chitosan microsphere properties. J. Microencapsul., 16, 697-703 (1999) DOI |
11 | Kokot, Z. and Zmidzinska, H., Solubility and dissolution rate of ibuprofen in ionic and non-ionic micellar systems, Acta Pol. Pharm., 58,117-120 (2001) |
12 | Constantin, M., Fundueanu, G., Bortolotti, F., Cortesi, R., Ascenzi, P., and Menegatti, E., Preparation and characterisation of poly(vinyl alcohol)/cyclodextrin microspheres as matrix for inclusion and separation of drugs. Int. J. Pharm., 285, 87-96 (2004) DOI ScienceOn |
13 | Kachrimanis, K., Nikolakakis, I., and Malamataris, S., Spherical crystal agglomeration of ibuprofen by the solvent-change technique in presence of methacrylic polymers. J. Pharm. Sci., 89, 250-259 (2000) DOI ScienceOn |
14 | Li, D. X., Piao, M. G., Kim, J. A., Yoo, B. K., Woo, J. S., Rhee, J. D., Lyoo, W. S., Han, S. S., Kim, C. K., Yong, C. S., and Choi, H. G., Development of ibuprofen-loaded gelatin microcapsule using gelatin gel by spray drying technique : dissolution and pharmacokinetics. Int. J. Pharm., accepted (2006) |
15 | Sahin, S., Selek, H., Ponchel, G., Ercan, M. T., Sargon, M., Hincal, A. A., and Kas, H. S., Preparation, characterization and in vivo distribution of terbutaline sulfate loaded albumin microspheres. J. Control. Rel., 82, 345-358 (2002) DOI ScienceOn |
16 | Menting, L. C., Hoogstad, B. and Thijssen, H. A. C., Diffusion coefficient of water and organic volatiles in carbohydratewater system. J. Food Technol., 5, 111-126 (1970) DOI |
17 | Charoenchaitrakool, M., Dehghani, F., and Foster, N. R., Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-beta-cyclodextrin. Int. J. Pharm., 239, 103-112 (2002) DOI ScienceOn |
18 | Murtha, J. L. and Ando, H. Y., Synthesis of the cholesteryl ester prodrugs cholesteryl ibuprofen and cholesteryl flufenamate and their formulation into phospholipid microemulsions, J. Pharm. Sci., 83, 1222-1228 (1994) DOI ScienceOn |
19 | Lee, S.W., Kim, M.H., and C. -K. Kim, Encapsulation of ethanol by spray drying technique: effects of sodium lauryl sulfate. Int. J. Pharm., 187, 193-198 (1999) DOI ScienceOn |
20 | Menting, L. C. and Hoogstad, B., Volatile retention during the drying aqueous carbohydrate solutions. J. Food Sci., 32, 87- 90 (1967) DOI |
21 | Ghorab, M.K. and Adeyeye, M.C., Enhancement of ibuprofen dissolution via wet granulation with beta-cyclodextrin. Pharm. Dev. Technol., 6, 305-314 (2001) DOI ScienceOn |
![]() |