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Cytotoxic C-Benzylated Chalcone and Other Constituents of Ellipeiopsis cherrevensis  

Wirasathien, Lalita (Faculty of Pharmaceutical Sciences, Chulalongkorn University)
Pengsuparp, Thitima (Faculty of Pharmaceutical Sciences, Chulalongkorn University)
Moriyasu, Masataka (Kobe Pharmaceutical University)
Kawanishi, Kazuko (Kobe Pharmaceutical University)
Suttisri, Rutt (Faculty of Pharmaceutical Sciences, Chulalongkorn University)
Publication Information
Archives of Pharmacal Research / v.29, no.6, 2006 , pp. 497-502 More about this Journal
Abstract
A new natural C-benzylated chalcone, $2 (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCl-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with $IC_{50}$ values of 1.40, 5.31 and $13.92\;{\mu}g/mL$, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an $IC_{50}$ value of $7.1\;{\mu}g/mL$ as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.
Keywords
Ellipeiopsis cherrevensis; Annonaceae; Flavonoids; Cyclohexene derivatives; Oxoaporphine alkaloid; Cyotoxicity;
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