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Synthesis and Evaluation of Biological Properties of Benzylide-neacetophenone Derivatives  

Oh, Sei-Kwan (Department of Neuroscience, College of Medicine, Ewha Womans University,Medical Science Institute, Ewha Womans University)
Jang, So-Yong (Department of Neuroscience, College of Medicine, Ewha Womans University)
Kim, Dong-Hyun (Medical Science Institute, Ewha Womans University)
Han, Inn-Oc (Department of Physiology, College of Medicine, Inha University)
Jung, Jae-Chul (Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi)
Publication Information
Archives of Pharmacal Research / v.29, no.6, 2006 , pp. 469-475 More about this Journal
Abstract
A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.
Keywords
Benzylideneacetophenones; Synthesis; Grignard reaction; NO generation; Free-radical scavenging; Cytotoxicity; Anti-excitotoxicity;
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