Blood-Brain Barrier Interfaces and Brain Tumors |
Lee Sae-Won
(Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Stroke and neurovascular regulation laboratory)
Kim Woo-Jean (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Neuroprotection research laboratory, Massachusetts General Hospital, Harvard Medical School) Park Jeong-Ae (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) Choi Yoon-Kyung (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) Kwon Yoo-Wook (Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases) Kim Kyu-Won (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) |
1 | Bazzoni, G., The JAM family of junctional adhesion molecules. Curr. Opin. Cell Biol., 15, 525-530 (2003) DOI ScienceOn |
2 | Breier, G., Breviario, F., Caveda, L., Berthier, R., Schnurch, H., Gotsch, U., Vestweber, D., Risau, W., and Dejana, E., Molecular cloning and expression of murine vascular endothelialcadherin in early stage development of cardiovascular system. Blood, 87, 630-641 (1996) |
3 | Bunn, H. F. and Poyton, R. O., Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev., 76, 839-885 (1996) DOI |
4 | Demeule, M., Regina, A., Jodoin, J., Laplante, A., Dagenais, C., Berthelet, F., Moghrabi, A., and Beliveau, R., Drug transport to the brain: Key roles for the efflux pump p-glycoprotein in the blood-brain barrier. Vas. Pharm., 38, 339-348 (2002) DOI ScienceOn |
5 | Ferrara, N. and Henzel, W. J., Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun., 161, 851-858 (1989) DOI ScienceOn |
6 | Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., and Tsukita, S., Occludin: a novel integral membrane protein localizing at tight junctions., J. Cell Biol., 123, 1777-1788 (1993) DOI |
7 | Gloor, S. M., Wachtel, M., Bolliger M. F., Ishihara, H., Landmann, R., and Frei, K., Molecular and cellular permeability control at the blood-brain barrier. Brain Res. Brain Res. Rev., 36, 258- 264 (2001) DOI ScienceOn |
8 | Haskins, J., Gu, L., Wittchen, E. S., Hibbard, J., and Stevenson, B. R., ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin., J. Cell Biol., 141, 199-208 (1998) DOI |
9 | Itoh, M., Morita, K., and Tsukita, S. H., Characterization of ZO-2 as a MAGUK family member associated with tight and adherens junctions with a binding affinity to occludin and . J. Biol. Chem., 274, 5981-5986 (1999b) DOI ScienceOn |
10 | Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., and Semenza, G. L., Cellular and developmental control of homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev., 12, 149-162 (1998) DOI |
11 | Lee, Y. M., Jeong, C. H., Koo, S. Y., Son, M. J., Song, H. S., Bae, S. K., Raleigh, J. A., Chung, H. Y., Yoo, M. A., and Kim, K. W., Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev. Dyn., 220, 175-186 (2001) DOI ScienceOn |
12 | Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., and Tsukita, S., Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol., 161, 653-660 (2003) DOI ScienceOn |
13 | Lindahl, P., Johansson, B. R., Leveen, P., and Betsholtz, C., Pericyte loss and microaneurysm formation in PDGF-Bdificient mice. Science 277., 242-245 (1997) DOI ScienceOn |
14 | Maltepe, E. and Simon, M.C., Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development. J. Mo.l Med., 76, 391- 401 (1998) DOI |
15 | Nagamatsu, S., Kornhauser, J. M., Burant, C. F., Seino, S., Mayo, K. E., and Bell, G. I., Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization. J. Biol. Chem., 267, 467- 472 (1992) |
16 | Pardridge, W. M., Boado, R. J., and Farrell, C. R., Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J. Biol. Chem., 265, 18035-18040 (1990) |
17 | Plate, K. H., Mechanism of angiogenesis in the brain. J. Neuropathol. Exp. Neurol., 58, 313-320 (1999) DOI |
18 | Risau, W., Mechanisms of angiogenesis. Nature, 386, 671-674 (1997) DOI ScienceOn |
19 | Saadoun, S., Papadopoulos, M. C., Davies, D. C., Krishna, S., and Bell, B. A., Aquaporin-4 expression is increased in oedematous human brain tumours. J. Neurol. Neurosurg. Psychiatry, 72, 262-265 (2002) DOI ScienceOn |
20 | Sandercoe, T. M., Geller, S. F., Hendrickson, A. E., Stone, J., and Provis, J. M., VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: evidence of developmental hypoxia. J. Comp. Neurol., 462, 42-54 (2003) DOI ScienceOn |
21 | Savettieri, G., Di Liegro, I., Catania, C., Licata, L., Pitarresi, G.L., D'Agostino, S., Schiera, G., De Caro, V., Giandalia, G., Giannola, L. I., and Cestelli, A., Neurons and ECM regulate occludin localization in brain endothelial cells. Neuroreport 11, 1081-1084 (2000) DOI ScienceOn |
22 | Schiera, G., Bono, E., Raffa, M. P., Gallo, A., Pitarresi, G. L., Di Liegro, I., and Savettieri, G., Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture. J. Cell Mol. Med., 7, 165-170 (2003) DOI |
23 | Zhong, Y., Saitoh, T., Minase, T., Sawada, N., Enomoto, K., and Mori, M., Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J. Cell Biol., 120, 477-483 (1993) DOI |
24 | Morita, K., Sasaki, H., Fujimoto, K., Furuse, M., and Tsukita, S., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and sertoli cells in testis. J. Cell Biol., 145, 579-588 (1999) DOI |
25 | Petty M. A. and Wettstein, J. G., Elements of cerebral microvascular ischaemia. Brain Res. Brain Res. Rev., 36, 23- 34 (2001) DOI ScienceOn |
26 | Richards, L. J., Kilpatrick, T. J., Dutton, R., Tan, S. S., Gearing, D. P., Bartlett, P. F., and Murphy, M., Leukaemia inhibitory factor or related factors promote the differentiation of neuronal and astrocytic precursors within the developing murine spinal cord. Eur. J. Neurosci., 8, 291-299 (1996) DOI ScienceOn |
27 | Takano, S., Yoshii, Y., Kondo, S., Suzuki, H., Maruno, T., Shirai, S., and Nose, T., Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res., 56, 2185-2190 (1996) |
28 | Wolburg, H., Wolburg-Buchholz, K., Kraus, J., Rascher- Eggstein, G., Liebner, S., Hamm, S., Duffner, F., Grote, E. H., Risau, W., and Engelhardt, B., Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol., 105, 586-592 (2003) |
29 | Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W., and Nagy, A., Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 380, 435-439 (1996) DOI ScienceOn |
30 | Harik, S. I., Kalaria, R. N., Andersson, L., Lundahl, P., and Perry, G., Immunocytochemical localization of the erythroid glucose transporter: abundance in tissues with barrier functions. J. Neurosci., 10, 3862-3872 (1990) DOI |
31 | Matter, K. and Balda, M. S., Holey barrier: claudins and the regulation of brain endothelial permeability. J. Cell Biol., 161, 459-460 (2003) DOI ScienceOn |
32 | Nicchia, G. P., Frigeri, A., Liuzzi, G. M., and Svelto, M., Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes. FASEB J., 17, 1508-1510 (2003) DOI |
33 | Ramsauer, M., Krause, D., and Dermietzel, R., Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes. FASEB J., 16, 1274-1276 (2002) DOI |
34 | Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., Lampugnani, M. G., Martin-Padura, I., Stoppacciaro, A., Ruco, L., McDonald, D. M., and Ward, P. A., Dejana, E., Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc. Natl. Acad. Sci. U.S.A., 96, 9815-9820 (1999) |
35 | Maher, F., Vannucci, S. J., and Simpson, I. A., Glucose transporter proteins in brain. FASEB J., 8, 1003-1011 (1994) DOI |
36 | Rieckmann, P. and Engelhardt, B., Building up the blood-brain barrier. Nat. Med., 9, 828-829 (2003) DOI ScienceOn |
37 | Folkman, J., Fundamental concepts of the angiogenic process. Curr. Mol. Med., 3, 643-651 (2003) DOI ScienceOn |
38 | Dehouck, M. P., Vigne, P., Torpier, G., Breittmayer, J. P., Cecchelli, R., and Frelin, C., Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillaries. J. Cereb. Blood Flow. Metab., 17, 464-469 (1997) DOI |
39 | Staddon, J. M. and Rubin, L. L., Cell adhesion, cell junctions and the blood-brain barrier. Curr. Opin. Neurobiol., 6, 622- 627 (1996) DOI ScienceOn |
40 | Wang, W., Dentler, W. L., and Borchardt, R. T., VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly. Am. J. Physiol. Heart Circ. Physiol., 280, H434-H440 (2001) DOI |
41 | Itoh, M., Sasaki, H., Furuse, M., Ozaki, H., Kita, T., and Tsukita, S., Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J. Cell Biol., 154, 491-497 (2001) DOI ScienceOn |
42 | McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H. F., Wolburg, H., Bader, B. L., Dvorak, A. M., and Hynes, R. O., Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol. Cell Biol., 22, 7667-7677 (2002) DOI |
43 | Mi, H., Haeberle, H., and Barres, B. A., Induction of astrocyte differentiation by endothelial cells. J. Neurosci., 21, 1538- 1547 (2001) DOI |
44 | Nico, B., Quondamatteo, F., Herken, R., Marzullo, A., Corsi, P., Bertossi, M., Russo, G., Ribatti, D., and Roncali, L., Developmental expression of ZO-1 antigen in the mouse blood-brain barrier. Brain Res. Dev. Brain Res., 114, 161-169 (1999) DOI ScienceOn |
45 | Papadopoulos, M. C., Saadoun, S., Woodrow, C. J., Davies, D. C., Costa-Martins, P., Moss, R. F., Krishna, S., and Bell, B. A., Occludin expression in microvessels of neoplastic and non-neoplastic human brain. Neuropathol. Appl. Neurobiol., 27, 384-395 (2001) DOI |
46 | Utsumi, H., Chiba, H., Kamimura, Y., Osanai, M., Igarashi, Y., Tobioka, H., Mori, M., and Sawada, N., Expression of GFRalpha-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB. Am. J. Physiol. Cell Physiol., 279, C361-C368 (2000) DOI |
47 | Gaillard, P. J., Voorwinden, L. H., Nielsen, J. L., Ivanov, A., Atsumi, R., Engman, H., Ringbom, C., de Boer, A. G., and Breimer, D. D., Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eu.r J. Pharm. Sci., 12, 215-222 (2001) DOI ScienceOn |
48 | Guerin, C., Laterra, J., Hruban, R. H., Brem, H., Drewes, L. R., and Goldstein, G. W., The glucose transporter and bloodbrain barrier of human brain tumors. Ann. Neurol., 28, 758- 765 (1990) DOI ScienceOn |
49 | Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E. H., Kalbacher, H., and Wolburg, H., Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiform. Acta Neuropathol., 100, 323-331 (2000) DOI |
50 | Fried, B. M. and Buckley, R. C., Primary carcinoma of the lungs. Arch. Pathol., 9, 483-527 (1930) |
51 | Huber, J. D., Egleton, R. D., and Davis, T. P., Molecular physiology and pathophysiology of tight junctions in the bloodbrain barrier. Trends Neurosci., 24, 719-725 (2001) DOI ScienceOn |
52 | Saitou, M., Furuse, M., Sasaki, H., Schulzke, J. D., Fromm, M., Takano, H., Noda, T., and Tsukita, S., Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell, 11, 4131-4142 (2000) DOI |
53 | Plate, K. H., Breier, G., Weich, H. A., Mennel, H. D., and Risau, W., Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int. J. Cancer, 59, 520-529 (1994) DOI ScienceOn |
54 | Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., Daly, T. J., Davis, S., Sato, T. N., and Yancopoulos, G. D., Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science, 277, 55-60 (1997) DOI ScienceOn |
55 | Verkman, A. S., Aquaporin water channels and endothelial cell function. J. Anat., 200, 617-627 (2002) DOI ScienceOn |
56 | Abbott, N. J., Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat., 200, 629-638 (2002) DOI ScienceOn |
57 | Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R., and Bertino, J. R., Multidrugresistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Pro.c Natl. Acad. Sci. U.S.A., 86, 695-698 (1989) |
58 | Kaur, B., Khwaja, F. W., Severson, E. A., Mathenyh, S. L., Brat, D. J., and Van Meir, E. V., Hypoxia and the hypoxia-induciblefactor pathway in glioma growth and angiogenesis. Neurooncol., 7, 134-153 (2005) |
59 | Nag, S., The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model. Trends Mol. Med., 8, 38- 44 (2002) DOI ScienceOn |
60 | Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C., Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem., 37, 159-164 (1989) DOI ScienceOn |
61 | Schnadelbach, O., Blaschuk, O. W., Symonds, M., Gour, B. J., Doherty, P., and Fawcett, J. W., N-cadherin influences migration of oligodendrocytes on astrocyte monolayers. Mol. Cell Neurosci., 15, 288-302 (2000) DOI ScienceOn |
62 | Bauer, H. C. and Bauer, H., Neural induction of the blood-brain barrier: still an enigma. Cell. Mol Neurobiology 20, 13-28 (2000) DOI ScienceOn |
63 | Engelhardt, B., Development of the blood-brain barrier. Cell Tissue Res., 314, 119-129 (2003) DOI |
64 | Martin-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., Simmons, D., and Dejana, E., Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J .Cell Biol., 142, 117- 127 (1998) DOI |
65 | Zhang, Y., Porat, R. M., Alon, T., Keshet, E., and Stone, J., Tissue oxygen levels control astrocyte movement and differentiation in developing retina. Brain Res. Dev. Brain Res., 118, 135-145 (1999) DOI ScienceOn |
66 | Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Moller, N. P., and Risau, W., A. Ullrich, High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell, 72, 835-846 (1993) DOI ScienceOn |
67 | Zhang, M. and Olsson, Y., Hematogenous metastases of the human brain-characteristics of peritumoral brain changes. J. Neurooncol., 35, 81-89 (1997) DOI |
68 | Kandel, E. R., Schwartz, J. H., and Jessell, T. M., Appendix B, Ventricular organization of cerebrospinal fluid: Blood-brain barrier, brain edema, and hydrocephalus, in: Principles of neural science (4th Eds). McGraw-Hill Companies, U.S.A., pp.1288-1301 (2000) |
69 | Risau, W. and Wolburg, H., Development of the BBB. Trends Neurosci., 13, 174-178 (1990) DOI ScienceOn |
70 | Song, H. S., Son, M. J., Lee, Y. M., Kim, W. J., Lee, S. W., Kim, C. W., and Kim, K. W., Oxygen tension regulates the maturation of the blood-brain barrier. Biochem. Biophys. Res. Commun., 290, 325-331 (2002) DOI ScienceOn |
71 | Manley, G. T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A. W., Chan, P., and Verkman, A. S., Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat. Med., 6, 159-163 (2000) DOI ScienceOn |
72 | Palmer, T. D., Willhoite, A. R., and Gage, F. H., Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol., 425, 479-494 (2000) DOI ScienceOn |
73 | Valter, M. M., Hugel, A., Huang, H. J., Cavenee, W. K., Wiestler, O. D., Pietsch, T. , and Wernert, N., Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. Cancer Res., 59, 5608-5614 (1999) |
74 | Rascher, G., Fischmann, A., Kroger, S., Duffner, F., Grote, E. H., and Wolburg, H., Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. Acta Neuropathol. (Berl), 104, 85-91 (2002) DOI ScienceOn |
75 | Enge, M., Bjarnegard, M., Gerhardt, H., Gustafsson, E., Kalen, M., Asker, N., Hammes, H. P., Shani, M., Fassler, R., and Betsholtz, C., Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J., 21, 4307-4316 (2002) DOI ScienceOn |
76 | Minagar, A., Long, A., Ma, T., Jackson, T. H., Kelley, R. E., Ostanin, D. V., Sasaki, M., Warren, A. C., Jawahar, A., Cappell, B., and Alexander, J. S., Interferon (IFN)-beta 1a and IFN-beta 1b block IFN-gamma-induced disintegration of endothelial junction integrity and barrier. Endothelium, 10, 299-307 (2003) DOI ScienceOn |
77 | Verkman, A. S. and Mitra, A. K., Structure and function of aquaporin water channels. Am. J. Pathology, 78, F13-F28 (2001) |
78 | Nico, B., Quondamatteo, F., Herken, R., Marzullo, A., Corsi, P., Bertossi, M., Russo, G., Ribatti, D., and Roncali, L., Developmental expression of ZO-1 antigen in the mouse blood-brain barrier. Brain Res. Dev. Brain Res., 114, 161-169 (1999) DOI ScienceOn |
79 | Saadoun, S., Papadopoulos, M. C., Davies, D. C., Bell, B. A., and Krishna, S., Increased aquaporin 1 water channel expression in human brain tumours. Br. J. Cancer, 87, 621- 623 (2002) DOI ScienceOn |
80 | Small, R. K., Watkins, B. A., Munro, P. M., and Liu, D., Functional properties of retinal Muller cells following transplantation to the anterior eye chamber. Glia, 7, 158-169 (1993) DOI |
81 | Citi, S., Sabanay, H., Jakes, R., Geiger, B., and Kendrick-Jones, J., Cingulin, a new peripheral component of tight junctions. Nature, 333, 272-276 (1988) DOI ScienceOn |
82 | Gelman, I. H., The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development. Front. Biosci., 7, d1782- d1797 (2002) DOI |
83 | Duelli, R. and Kuschinsky, W., Brain glucose transporters: relationship to local energy demand. News Physiol. Sci., 16, 71-76 (2001) |
84 | Janzer, R. C. and Raff, M. C., Astrocytes induce blood-brain barrier properties in endothelial cells. Nature, 325, 253-257 (1987) DOI ScienceOn |
85 | Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., and Tsukita, S., Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol., 141, 1539-1550 (1998) DOI |
86 | Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., and Tsukita, S., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol., 147, 1351-1363 (1999a) DOI |
87 | Kleihues P. and Cavanee W. K., (Eds.), Tumors of the Nervous System. World Health Organization Classification of Tumors. Pathology and Genetics. IARC Press, Vol 1., Lyon (2000) |
88 | Walker, P. S., Donovan, J. A., Van Ness, B. G., Fellows, R. E., and Pessin, J. E., Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells. J. Biol. Chem., 263, 15594-15601 (1988) |
89 | Tran, N. D., Correale, J., Schreiber, S. S., and Fisher, M., Transforming growth factor-beta mediates astrocyte-specific regulation of brain endothelial anticoagulant factors. Stroke, 30, 1671-1678 (1999) DOI ScienceOn |
90 | Abbott, N. J., Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat., 200, 629-638 (2002) DOI ScienceOn |
91 | Hirase, T., Staddon, J. M., Saitou, M., Ando-Akatsuka, Y., Itoh, M., Furuse, M., Fujimoto, K., Tsukita, S., and Rubin, L. L., Occludin as a possible determinant of tight junction permeability in endothelial cells. J. Cell Sci., 110, 1603-1613 (1997) |
92 | Breier, G., Albrecht, U., Sterrer, S., and Risau, W., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development, 114, 521-532 (1992) |
93 | Genbacev, O., Zhou, Y., Ludlow, J. W., and Fisher, S. J., Regulation of human placental development by oxygen tension. Science, 277, 1669-1672 (1997) DOI ScienceOn |
94 | Lee, S. W., Kim, W. J., Choi, Y. K., Song, H. S., Son, M. J., Gelman, I. H., Kim, and Y. J., Kim, K. W., SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat. Med., 9, 900-906 (2003) DOI ScienceOn |
95 | Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., and Holash, J., Vascular-specific growth factors and blood vessel formation. Nature, 407, 242-248 (2000) DOI ScienceOn |
96 | Lampugnani, M. G., Corada, M., Caveda, L., Breviario, F., Ayalon, O., Geiger, B., and Dejana, E., The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J. Cell Biol., 129, 203-217 (1995) DOI |
97 | Antonetti, D. A., Barber, A. J., Hollinger, L. A., Wolpert, E. B., and Gardner, T. W., Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J. Biol. Chem., 274, 23463-23467 (1999) DOI |
98 | Collins, V. P., Cellular mechanisms targeted during astrocytoma progression., Cancer Lett., 188, 1-7 (2002) DOI ScienceOn |
99 | Fanning, A. S., Jameson, B. J., Jesaitis, L. A., and Anderson, J. M., The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem., 273, 29745-29753 (1998) DOI |
100 | Igarashi, Y., Utsumi, H., Chiba, H., Yamada-Sasamori, Y., Tobioka, H., Kamimura, Y., Furuuchi, K., Kokai, Y., Nakagawa, T., Mori, M., and Sawada, N., Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier. Biochem. Biophys. Res. Commu., n 261, 108-112 (1999) |
101 | Reuss, B., Dono, R., and Unsicker, K., Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J. Neurosci., 23, 6404-6412 (2003) DOI |
102 | Wolburg, H. and Lippoldt, A., Tight junctions of the blood-brain barrier: Development, composition and regulation. Vas. Pharmacol., 38, 323-337 (2002) DOI ScienceOn |