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Cytotoxic Activity of Four Xanthones from Emericella variecolor, an Endophytic Fungus Isolated from Croton oblongifolius  

Pornpakakul Surachai (Research Centre for Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University)
Liangsakul Jatupol (Program of Biotechnology, Chulalongkorn University)
Ngamrojanavanich Nattaya (Research Centre for Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University)
Roengsumran Sophon (Research Centre for Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University)
Sihanonth Prakitsin (Department of Microbiology, Chulalongkorn University)
Piapukiew Jittra (Department of Botany, Faculty of Science, Chulalongkorn University)
Sangvichien Ek (Department of Biology, Faculty of Science, Ramkhamhang University)
Puthong Songchan (Institute of Biotechnology and Genetic Engineering, Chulalongkorn University)
Petsom Amorn (Institute of Biotechnology and Genetic Engineering, Chulalongkorn University)
Publication Information
Archives of Pharmacal Research / v.29, no.2, 2006 , pp. 140-144 More about this Journal
Abstract
Four xanthones were isolated from mycelia of Emericella variecolor, an endophytic fungus isolated from the leaves of Croton oblongifolius. Their structures were elucidated by spectroscopic analysis to be shamixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone methanoate, and tajixanthone hydrate. All compounds were tested for cytotoxic activity against various human tumor cell lines including gastric carcinoma, colon carcinoma, breast carcinoma, human hepatocarcinoma, and lung carcinoma. The antitumor activities of these xanthones were compared with that of doxorubicin hydrochloride, a chemotherapeutic substance. All of them showed moderate activities and were selective against gastric carcinoma, colon carcinoma, and breast carcinoma. Only tajixanthone hydrate exhibited moderate activity against all cancer cell lines. Furthermore, under the test conditions it was found that 14-methoxytajixanthone-25-acetate and tajixanthone hydrate are almost as active as doxorubicin hydrochloride against gastric carcinoma (KATO3) and breast carcinoma (BT474).
Keywords
Emericella variecolor; Shamixanthone; 14-Methoxytajixanthone-25-acetate; Tajixanthone methanoate; Tajixanthone hydrate; Cytotoxic activity; Endophyte;
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Times Cited By Web Of Science : 7  (Related Records In Web of Science)
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