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Inhibitory Activity of 6-O-Angeloylprenolin from Centipeda minima on Farnesyl Protein Transferase  

Oh, Hyun-Mi (Korea Research Institute of Bioscience and Biotechnology, KIST)
Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST)
Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Kim, Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University)
Lee, Jae-Hyeok (Department of Oriental Pharmaceutical development, Nambu University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.29, no.1, 2006 , pp. 64-66 More about this Journal
Abstract
The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of 6-O-angeloylprenolin was 18.8 ${\mu}M$.
Keywords
Centipeda minima; 6-O-Angeloylprenolin; FPTase;
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Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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