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Secalonic acid D; A Cytotoxic Constituent from Marine Lichen-derived Fungus Gliocladium sp. T31  

Ren, Hong (Key Laboratory of Marine Drug Chinese Ministry of Education, Institute of Marine Drug and Food, Ocean University of China)
Tian, Li (Science & technology college of Chemistry and Biology, Yantai University)
Gu, Qianqun (First Institute of Oceanography, State Oceanic Administration)
Zhu, Weiming (Qingdao University of Science & Technology)
Publication Information
Archives of Pharmacal Research / v.29, no.1, 2006 , pp. 59-63 More about this Journal
Abstract
Secalonic acid D(SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
Keywords
Marine lichen-derived; Gliocladium sp.; Secalonic acid D; Cytotoxicity; Cell cycle inhibition;
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