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Synthesis of Diacetoxy Acetal Derivatives of Santonin and their Enhancing Effects on HL-60 Leukemia Cell Differentiation  

Kim, Seung-Hyun (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Chung, Sun-Young (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Kim, Tae-Sung (School of Life Sciences and Biotechnology, Korea University)
Choi, Bo-Gil (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Publication Information
Archives of Pharmacal Research / v.29, no.1, 2006 , pp. 40-45 More about this Journal
Abstract
Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin $D_3[1,25-(OH)_2D_3]-induced$ HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin $D_3[1,25(OH)_2O_3]$, a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the $1,25-(OH)2O_3]-induced$ HL-60 cell differentiation.
Keywords
Diacetoxyacetal; Santonin; Leukemia cell differentiation; Dihydroxyvitamin $D_3$;
Citations & Related Records

Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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