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Monoamine Oxidase Inhibitory Coumarins from the Aerial Parts of Dictamnus albus  

Jeong, Seon-Hwa (College of Pharmacy, Chungbuk National University)
Han, Xiang Hua (College of Pharmacy, Chungbuk National University)
Hong, Seong-Su (College of Pharmacy, Chungbuk National University)
Hwang, Ji-Sang (College of Pharmacy, Chungbuk National University)
Hwang, Ji-Hye (College of Pharmacy, Chungbuk National University)
Lee, Dong-Ho (Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Lee, Myung-Koo (College of Pharmacy, Chungbuk National University)
Ro,, Jai-Seup (College of Pharmacy, Chungbuk National University)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Publication Information
Archives of Pharmacal Research / v.29, no.12, 2006 , pp. 1119-1124 More about this Journal
Abstract
The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6'R-hydroxy-3', 7'-dimethyl-2'E, 7'-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 0.7 and $1.7\;{\mu}M$, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B ($IC_{50}\;0.5\;and\;0.6\;{\mu}M,\;respectively$) compared to MAO-A ($IC_{50}\;1.3\;and\;34.6\;{\mu}M,\;respectively$). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.
Keywords
Dictamnus albus; Rutaceae; Coumarin; Monoamine oxidase inhibitor;
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