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Anti-inflammatory Activity of Flavonoids from Populus davidiana  

Zhang, XinFeng (College of Pharmacy, Chungnam National University)
Hung, Tran Manh (College of Pharmacy, Chungnam National University)
Phuong, Phuong Thien (College of Pharmacy, Chungnam National University)
Ngoc, Tran Minh (College of Pharmacy, Chungnam National University)
Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Song, Kyung-Sik (College of Agriculture and Life Science, Kyungbuk National University)
Seong, Yeon-Hee (College of Veterinary Medicine, Chungbuk National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.29, no.12, 2006 , pp. 1102-1108 More about this Journal
Abstract
An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark of Populus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4'-di-${\beta}$-D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds, 1-10, were tested for their inhibitory activities against COX-1 and COX-2. Compound 7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds 1-6 showed moderate inhibition against COX-1 only. Moreover, compounds 5-8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses of P. davidiana in ethnomedicine.
Keywords
Populus davidiana; Flavonoids; Anti-inflammatory; Cyclooxygenase; Xanthine oxidase;
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