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Synthesis, Cytotoxicity and Structure-Activity Relationship Study of Terpyridines  

Zhao, Long-Xuan (Department of Chemistry, Liaoning Normal University)
Sherchan, Jyoti (College of Pharmacy, Yeungnam University)
Park, Jung-Ki (College of Pharmacy, Yeungnam University)
Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
Jeong, Byeong-Seon (College of Pharmacy, Yeungnam University)
Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
Lee, Chong-Soon (Department of Biochemistry, Yeungnam University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.29, no.12, 2006 , pp. 1091-1095 More about this Journal
Abstract
For the development of novel antitumor agents, we designed and synthesized terpyridines, and their biological activities were evaluated. Although most of the newly prepared terpyridines showed strong cytotoxicity against several human cancer cell lines, [2,2';6',2"]-terpyridine displayed the most significant cytotoxicity.
Keywords
Terpyridines; Cytotoxicity; Topoisomerase I inhibition; Antitumor agent; Synthesis;
Citations & Related Records

Times Cited By Web Of Science : 20  (Related Records In Web of Science)
Times Cited By SCOPUS : 16
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