Browse > Article

Cytotoxic Phenolic Constituents of Acer tegmentosum Maxim  

Park, Ki-Myun (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Yang, Min-Cheol (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Lee, Kyu-Ha (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Kim, Kyung-Ran (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Publication Information
Archives of Pharmacal Research / v.29, no.12, 2006 , pp. 1086-1090 More about this Journal
Abstract
The chromatographic separation of the MeOH extract from the twigs of Acer tegmentosum led to the isolation of ten phenolic compounds. The structures of these compounds were determined using spectroscopic methods as 3,7,3',4'-tetramethyl-quercetin (1), 5,3'-dihydroxy-3,7,4'-trimethoxy flavone (2), 2,6-dimethoxy-p-hydroquinone (3), (-)-catechin (4), morin-3-O-${\alpha}$-L-lyxoside (5), p-hydroxy phenylethyl-O-${\beta}$-D-glucopyranoside (6), 3,5-dimethoxy-4-hydroxy phenyl-1-O-${\beta}$-D-glucoside (7), fraxin (8), 3,5-dimethoxy-benzyl alcohol 4-O-${\beta}$-D-glucopyranoside (9) and 4-(2,3-dihydroxy propyl)-2,6-dimethoxy phenyl ${\beta}$-D-glucopyranoside (10). The compounds were examined for their cytotoxic activity against five cancer cell lines. Compound 3 exhibited good cytotoxic activity against five human cancer cell lines with $ED_{50}$ values ranging from $1.32\;to\;3.85\;{\mu}M$.
Keywords
Acer tegmentosum; Acereaceae; Phenolic glycosides; Cytotoxicity;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Bilia, A. R., Morelli, I., Hamburger M., and Hostettmann, K., Flavanes and a-type proanthocyanidins from Prunus prostrata., Phytochemistry, 43, 887-892 (1996)   DOI   ScienceOn
2 Emi, O., Tetsuya, H., Takamitsu, M., Haruhiro, F., Masami, I., and Mikio, Y., Analgesic Components of Saposhnikovia Root (Saposhnikovia divaricata)., Chem. Pharm. Bull., 49, 154- 160 (2001)   DOI   ScienceOn
3 Hideaki, O., Mami, T., Shogo, I., Tomohiro, S., and Kazuo, Y., Phenolic compounds from Coix lachryma-jobi var. ma-yuen., Phytochemistry, 28, 883-886 (1989)   DOI   ScienceOn
4 Hatano, T., Hattori, S., Ikeda, Y., Shingu, T., and Okuda, Y., Tannins of Aceraceous plants. Part II. Gallotannins having a 1,5-anhydro-D-glucitol core and some ellagitannins from Acer species., Chem. Pharm. Bull., 38, 1902-1905 (1990)   DOI
5 Ying, W., Matthias, H., Joseph, G., and Kurt, H., Antimicrobial flavonoids from Psiadia trinervia and their methylated and acetylated derivatives. Phytochemistry, 28, 2323-2327 (1989)   DOI   ScienceOn
6 Junichi, K., Toru, I., Yasuko, T., Masateru, O., Yasuyuki, I., and Toshihiro, N., Water soluble constituents of Fennel. V Glycosides of Aromatic compounds. Chem. Pharm. Bull., 46, 1587-1590 (1998)   DOI
7 Hidetoshi, A. and Gen, I. D., Isolation of antimicrobial compounds from Guava (Pisdium guajava L.) and their structural elucidation. Biosci. Biotechnol. Biochem., 66, 1727-1730 (2002)   DOI   ScienceOn
8 Jorn, L., Alfred, B., Thomas, D., Turgen, S., Vidtor, W., Dierk, S., Dieter, S., and Sabine, R., Accumulation of tyrosol glucoside in transgenic potato plants expressing a parsley tyrosine decarboxylase. Hiroko Oguchi, Ionone and lignan glycosides from Epimedium diphyllum. Phytochemistry, 60, 683-689 (2002)   DOI   ScienceOn
9 Kangi, I., Gen, I. N., and Itsuo, N., Flavan-3-ol and procyanidin glycosides from Quercus miygii., Phytochemistry, 26, 1167- 1170 (1987)   DOI   ScienceOn
10 Adolf, H., Peter, P., and Eric, E. Conn., Dhurrin, (-)-catechin, flavonol glycosides and flavones from Chamaebatia foliolosa. Phytochemistry, 26, 1546-1547 (1987)   DOI   ScienceOn
11 Masataka, S. and Masao, K., Studies on the constituents of Osmantus species. X. Structures of phenolic glucosides form the leaves of Osmanthus asiaticus Nakai. Chem. Pharm. Bull., 40, 325-326 (1992)   DOI
12 Kubo, M., Nagai, M., and Inoue, T., Studies on the constituents of ceraceae plants. Carbon-13 nuclear magnetic resonance spectra of acerogenin A, rhododendrol, and related compounds, and structure of aceroside from Acer nikoense. Chem. Pharm. Bull., 31, 1917-1922 (1983)   DOI
13 Kubo, M., Inoue, T., and Nagai, M., Studies on the constituents of aceraceae plants. III. Structure of acerogenin B from Acer nikoense Maxim. Chem. Pharm. Bull., 28, 1300-1303 (1980)   DOI
14 Hideyuki, M., Hiroyuki, M., Chikako, A., Midori, A., Teruhiko, Y., and Junya, M., Isolation of ${\alpha}$-glucosidase inhibitors from hyssop (Hyssopus officinalis). Phytochemistry, 65, 91-97 (2004)   DOI   ScienceOn
15 Kanji, I., Hiroshi, S., Motoyoshi, S., and Koichiro, S., Phenyl glucosides from hairy root culture of Swertia jponica. Phytochemistry, 29, 3823-3825 (1990)   DOI   ScienceOn
16 Hefeng, P. and Lennart, N. L., Phenolics from inner bark of Pinus sylvestris., Phytochemistry, 42, 1185-1189 (1996)   DOI   ScienceOn
17 Stephen, J. P., Louise, N. J., and David, C. P., High-resolution $^1H$- and $^{13}C$-NMR. Spectra of D-glucopyranose, 2-acetamido- 2-deoxy-D-glucopyranose, and related compounds in aqueous media. Carbohydrate Research, 59, 19-34 (1977)   DOI   ScienceOn
18 Renmin, L., Qinghua, S., Ailing, S., and Jichun, C., Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography. J. Chromatogr. A., 1072, 195-199 (2005)   DOI   ScienceOn
19 Ahn, D. K., Illustrated Book of Korean Medicinal Herbs. Kyo- Hak publishing, Seoul, p 523 (1998)