Antiplatelet and Antithrombotic Activities of Korean Red Ginseng
![]() ![]() |
Yu, Ji-Yeon
(College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University)
Jin, Yong-Ri (Research Institute of Veterinary Medicine, Chungbuk National University) Lee, Jung-Jin (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Chung, Jin-Ho (College of Pharmacy, Seoul National University) Noh, Ji-Yoon (College of Pharmacy, Seoul National University) You, Soon-Hyang (Department of Food and Nutrition, Chungbuk National University) Kim, Ki-Nam (Department of Food and Nutrition, Chungbuk National University) Im, Ji-Hyun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Lee, Ju-Hyun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Seo, Ji-Min (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Han, Hyeong-Jun (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Lim, Yong (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Park, Eun-Seok (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Kim, Tack-Joong (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) Shin, Kyeong-Soeb (College of Medicine, Chungbuk National University) Wee, Jae-Joon (KT & G Central Research Institute) Park, Jong-Dae (KT & G Central Research Institute) Yun, Yeo-Pyo (College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University) |
1 | Furie, B. and Furie, B. C., Thrombus formation in vivo. J. Clin. Invest., 115, 3355-3362 (2005) DOI ScienceOn |
2 | Holmsen, H. and Dangelmarier, C. A., Measurement of secretion of serotonin. Methods Enzymol., 169, 205-210 (1989) DOI |
3 | Jackson, S. P., Nesbitt, W. S., and Kulkarni, S., Signaling events underlying thrombus formation. J. Thromb. Haemost., 1, 1602-1612 (2003) DOI ScienceOn |
4 |
Jin, Y. R., Cho, M. R., Ryu, C. K., Chung, J. H., Yuk, D. Y., Hong, J. T., Lee, K. S., Lee, J. J., Lee, M. Y., Lim, Y., and Yun, Y. P., Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'- fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic |
5 | Cui, X., Sakaguchi, T., Shirai, Y., and Hatakeyama, K., Orally administered Panax ginseng extract decreases platelet adhesiveness in 66% hepatectomized rats. Am. J. Chin. Med., 27, 251-256 (1999) DOI ScienceOn |
6 | Blockmans, D., Deckmyn, H., and Vermylen, J., Platelet activation. Blood Rev., 9, 143-156 (1995) DOI ScienceOn |
7 | Jin, Y. R., Ryu, C. K., Moon, C. K., Cho, M. R., and Yun, Y. P., Inhibitory effects of J78, a newly synthesized 1, 4- naphthoquinone derivative, on experimental thrombosis and platelet aggregation. Pharmacology, 70, 195-200 (2004) DOI ScienceOn |
8 | Sarratt, K. L., Chen, H., Zutter, M. M., Santoro, S. A., Hammer, D. A., and Kahn, M. L., GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood, 106, 1268-1277 (2005) DOI ScienceOn |
9 | Baek, N. I., Kim, D. S., Lee, Y. H., Park, J. D., Lee, C. B., and Kim, S. I., Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Med., 62, 86-87 (1996) DOI ScienceOn |
10 | Chen, X., Experimental study on the cardiovascular effects of ginsenosides. Zhonghua Xin Xue Guan Bing Za Zhi, 10, 147- 150 (1982) |
11 | Gillis, C. N., Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol., 54, 1-8 (1997) DOI ScienceOn |
12 | Cowan, D. H., Platelet adherence to collagen: role of prostaglandin-thromboxane synthesis. Br. J. Haematol., 49, 425-434 (1981) DOI ScienceOn |
13 |
Park, H. J., Rhee, M. H., Park, K. M., Nam, K. Y., and Park, K. H., Effect of non-saponin fraction from Panax ginseng on cGMP and thromboxane |
14 | Gruner, S., Prostredna, M., Aktas, B., Moers, A., Schulte, V., Krieg, T., Offermanns, S., Eckes, B., and Nieswandt, B., Antiglycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy. Circulation, 110, 2946-2951 (2004) DOI ScienceOn |
15 | Cowan, D. H., Robertson, A. L., Shook, P., and Giroski, P., Platelet adherence to collagen: role of plasma, ADP, and divalent cations. Br. J. Haematol., 47, 257-267 (1981) DOI ScienceOn |
16 | Park, J. H., Cha, H. Y., Seo, J. J., Hong, J. T., Han, K., and Oh, K. W., Anxiolytic-like effects of ginseng in the elevated plusmaze model: comparison of red ginseng and sun ginseng. Prog. Neuropsychopharmacol. Biol. Psychiatry, 29, 895-900 (2005) |
17 | Woulfe, D. S., Platelet G protein-coupled receptors in hemostasis and thrombosis. J. Thromb. Haemost., 3, 2193- 2200 (2005) DOI ScienceOn |
18 | Farndale, R. W., Sixma, J. J., Barnes, M. J., and De Groot, P. G., The role of collagen in thrombosis and hemostasis. J. Thromb. Haemost., 2, 561-573 (2004) DOI ScienceOn |
19 | Born, G. V. and Cross, M. J., The aggregation of blood platelets. J. Physiol., 168, 178-195 (1963) DOI |
20 | Sarratt, K. L., Chen, H., Kahn, M. L., and Hammer, D. A., Platelet receptor glycoprotein VI-mediated adhesion to type I collagen under hydrodynamic flow. Ann. Biomed. Eng., 32, 970-976 (2004) DOI ScienceOn |
![]() |