Mutant Presenilin 2 Causes Abnormality in the Brain Lipid Profile in the Development of Alzheimer's Disease
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Nguyen, Hong Nga
(College of Pharmacy and CBITRC, Chungbuk National University)
Son, Dong-Ju (College of Pharmacy and CBITRC, Chungbuk National University) Lee, Jae-Woong (College of Pharmacy and CBITRC, Chungbuk National University) Hwang, Dae-Youn (National Institute of Toxicological Research, Korea Food and Drug Administration) Kim, Young-Kyu (National Institute of Toxicological Research, Korea Food and Drug Administration) Cho, Jeong-Sik (National Institute of Toxicological Research, Korea Food and Drug Administration) Lee, Ung-Soo (Department of Food and Biotechnology, Chungju National University) Yoo, Hwan-Soo (College of Pharmacy and CBITRC, Chungbuk National University) Moon, Dong-Cheul (College of Pharmacy and CBITRC, Chungbuk National University) Oh, Ki-Wan (College of Pharmacy and CBITRC, Chungbuk National University) Hong, Jin-Tae (College of Pharmacy and CBITRC, Chungbuk National University) |
1 |
Fassbender, K., Simons, M., and Bergmann, C., Simvastatin strongly reduces levels of Alzheimer's disease |
2 | Irizarry, M. C., Deng, A., Lleo, A., Berezovska, O., Von Arnim, C. A., Martin-Rehrmann, M., Manelli, A., LaDu, M. J., Hyman, B. T., and Rebeck, G. W., Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J. Neurochem., 90, 1132-1143 (2004) DOI ScienceOn |
3 | Lee, S. Y., Hwang, D. Y., Kim, Y. K., Lee, J. W., Shin, I. C., Oh, K. W., Lee, M. K., Lim, J. S., Yoon, do. Y., Hwang, S. J., and Hong, J. T., PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase- 3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J., 20,151-153 (2006) DOI ScienceOn |
4 | Simons, K. and Ikonen, E., How cells handle cholesterol. Science, 290, 1721-1726 (2000) DOI ScienceOn |
5 | Tan, Z. S., Seshadri, S., and Beiser, A., Plasma total cholesterol level as a risk factor for Alzheimer's disease: the Framingham study. Arch. Intern. Med., 163, 1053-1057 (2003) DOI ScienceOn |
6 | Wahrle, S., Das, P., and Nyborg, A. C., Cholesterol-dependent g-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis., 9, 11-23 (2002) DOI ScienceOn |
7 | Refolo, L. M., Pappolla, M. A., and La Francois, J., A cholesterol-lowering drug reduces b-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis., 8, 890-899 (2001) DOI ScienceOn |
8 | Ignatius, M. J., Gebicke-Harter, P. J., and Skene, J. H., Expression of apolipoprotein E during nerve degeneration and regeneration. Proc. Natl. Acad. Sci. U.S.A., 83, 1125-1129 (1986) |
9 | Buxbaum, J. D., Geoghagan, N. S., and Friedhoff, L. T., Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J. Alzheimers Dis., 3, 221-229 (2001) DOI |
10 | Koudinov, A. R., Berezov, T. T., and Kumar, A., Alzheimer's amyloid b interaction with normal human plasma high density lipoprotein: association with apolipoprotein and lipids. Clin. Chim. Acta., 270, 75-84 (1998) DOI ScienceOn |
11 | Sawamura, N., Morishima-Kawashima, M., Waki, H., Kobayashi, K., Kuramochi, T., Frosch, M. P., Ding, K., Ito, M., Kim, T. W., Tanzi, R. E., Oyama, F., Tabira, T., Ando, S., and Ihara, Y., Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J. Biol. Chem., 275, 27901-27908 (2000) |
12 | Janicki, S. and Monteiro, M. J., Increased apoptosis arising from increased expression of the Alzheimer's diseaseassociated presenilin-2 mutation (N141I). J. Cell Biol., 139, 485-495 (1997) DOI |
13 | Galbete, J. L., Martin, T. R., Peressini, E., Modena, P., Bianchi, R., and Forloni, G., Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway. Biochem. J., 348, 307-313 (2000) DOI |
14 | Pappolla, M. A., Bryant-Thomas, T. K., and Herbert, D., Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology, 61, 199- 205 (2003) DOI ScienceOn |
15 | De Sarno, P., Lesort, M., Bijur, G. N., Johnson, G. V., and Jope, R. S., Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1. Brain Res., 903, 226-230 (2001) DOI ScienceOn |
16 | Deng, G., Pike, C. J., and Cotman, C. W., Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett., 397, 50-54 (1996) DOI ScienceOn |
17 | Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A., Statins and the risk of dementia. Lancet, 356, 1627-1631 (2000) DOI ScienceOn |
18 | Refolo, L. M., Malester, B., La Francois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., Duff, K., and Pappolla, M. A., Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis., 7, 321-331 (2000) DOI ScienceOn |
19 | Diebold, K., Michel, G., Schweizer, J., Diebold-Dorsam, M., Fiehn, W., and Kohl, B., Are psychoactive-drug-induced changes in plasma lipid and lipoprotein levels of significance for clinical remission in psychiatric disorders- Pharmacopsychiatry, 31, 60-67 (1998) DOI ScienceOn |
20 | Hwang, D. Y., Chae, K. R., Kang, T. S., Hwang, J. H., Lim, C. H., Kang, H. K., Goo, J. S., Lee, M. R., Lim, H. J., Min, S. H., Cho, J. Y., Hong, J. T., Song, C. W., Paik, S. G., Cho, J. S., and Kim, Y. K., Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J., 16, 805-813 (2002) DOI ScienceOn |
21 | Wellington, C. L., Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism. Clin. Genet., 66, 1-16 (2004) DOI ScienceOn |
22 | Burns, M., Gaynor, K., and Olm, V., Presenilin redistribution associated with aberrant cholesterol transport enhances bamyloid production in vivo. J. Neurosci., 23, 5645-5649 (2003) DOI |
23 | Runz, H., Rietdorf, J., Tomic, I., de Bernard, M., Beyreuther, K., Pepperkok, R., and Hartmann, T., Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J. Neurosci., 22, 1679-1689 (2002) DOI |
24 | Subasinghe, S., Unabia, S., Barrow, C. J., Mok, S. S., Aguilar, M. I., and Small, D. H., Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes. J. Neurochem., 84, 471-479 (2003) DOI ScienceOn |
25 | Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K., Troncoso, J. C., and Mattson, M. P., Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A., 101, 2070-2075 (2004) |
26 | Ehehalt, R., Keller, P., and Haass, C., Amyloidogenic processing of the Alzheimer b-amyloid precursor protein depends on lipid rafts. J. Cell Biol., 60, 113-123 (2003) |
27 | Shie, F. S., Jin, L. W., and Cook, D. G., Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport, 213, 455-459 (2002) |
28 | Michikawa, M., Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease? J. Neurosci. Res., 72, 141-146 (2003) DOI ScienceOn |
29 | Mori, M., Nakagami, H., Morishita, R., Mitsuda, N., Yamamoto, K., Yoshimura, S., Ohkubo, N., Sato, N., Ogihara, T., and Kaneda, Y., N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci., 70, 2567-2580 (2002) DOI ScienceOn |
30 | Koudinov, A. R., Berezov, T. T., and Koudinov, N. V., The levels of soluble amyloid beta in different high density lipoprotein subfractions distinguish Alzheimer's and normal aging cerebrospinal fluid: implication for brain cholesterol pathology? Neurosci. Lett., 314, 115-118 (2001) DOI ScienceOn |
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