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Trials of Novel $^{13}C-Urea-Containing$ Capsule for More Economic and Sensitive Diagnosis of Helicobacter pylori Infection in Human Subjects  

Yong, Chul-Soon (College of Pharmacy, Yeungnam University)
Kim, Yong-Il (College of Pharmacy, Yeungnam University)
Park, San-Man (College of Pharmacy, Yeungnam University)
Kwon, Rham (College of Pharmacy, Yeungnam University)
Han, Hong-Hee (College of Pharmacy, Yeungnam University)
Park, Jung-Gil (College of Pharmacy, Yeungnam University)
Yang, Chan-Yoo (College of Pharmacy, Yeungnam University)
Kim, Jung-Ae (College of Pharmacy, Yeungnam University)
Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University)
Rhee, Jong-Dal (College of Pharmacy, Yeungnam University)
Choi, Han-Gon (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.29, no.10, 2006 , pp. 879-883 More about this Journal
Abstract
To develop a $^{13}C-urea-containing$ capsule for more economic and sensitive diagnosis of Helicobacter pylori infection, the $^{13}C-urea-containing$ capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and $^{13}C-urea$ Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference ${\sigma}$ $^{13}C$ values from $^{13}C-urea$, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from $^{13}C-urea$ compared to a commercial 76 mg $^{13}C-urea-containing$ capsule due to higher initial dissolution rate. The capsules with 38 mg $^{13}C-urea$ and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about $8{\textperthousand}$ at 10 min, improved the sensitivity of $^{13}C-urea$ in human volunteers. Thus, the $^{13}C-urea-containing$ capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection.
Keywords
Helicobacter pylori; Urea; Polyethylene glycol; Dissolution; $^{13}C-Urea$ breath test;
Citations & Related Records

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