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Constituents of the Roots of Pueraria Iobata Inhibit Formation of Advanced Glycation End Products (AGEs)  

Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Lee, Ga-Young (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Archives of Pharmacal Research / v.29, no.10, 2006 , pp. 821-825 More about this Journal
Abstract
Two isoflavone C-glucosides, puerarin (1) and PG-3 (2), a but-2-enolide, $({\pm})-puerol$ B (3), two isoflavone O-glucosides, daidzin (4) and genistin (5), and three pterocarpans, (-)-medicarpin (6), (-)-glycinol (7) and (-)-tuberosin (8), were isolated from a MeOH extract of the roots of Pueraria Iobata, using an in vitro bioassay based on the inhibition of the formation of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1-8 were determined by spectroscopic data interpretation, particularly by 1D- and 2D-NMR studies, and by comparison of these data with values in the literature. All of the isolates (1-8) were evaluated for their inhibitory activity on AGEs formation in vitro. Of these, puerarin (1), PG-3 (2), and $({\pm})-puerol$ B (3) exhibited more potent inhibitory activity than the positive control aminoguanidine.
Keywords
Pueraria Iobata; Leguminosae; Puerarin; PG-3; $({\pm})-Puerol$ B; Advanced glycation end products (AGEs); Diabetic complications;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 8  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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