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Trichodermamide A and Aspergillazine A, Two Cytotoxic Modified Dipeptides from a Marine-Derived Fungus Spicaria elegans  

Liu Rui (Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Gu Qian-Qun (Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Zhu Wei-Ming (Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Cui Cheng-Bin (Beijing Institute of Pharmacology and Toxicology, AMMS)
Fan Guo-Tao (Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Publication Information
Archives of Pharmacal Research / v.28, no.9, 2005 , pp. 1042-1046 More about this Journal
Abstract
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
Keywords
Marine-derived fungus; Spicaria elegans; Trichodermamide A (penicillazine); Aspergillazine A; Modified dipeptides; Cytotoxic activity;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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