Browse > Article

A New Furofuran Lignan with Antioxidant and Antiseizure Activities from the Leaves of Petasites japonicus  

Min Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Cui Hui Song (College of Pharmacy, Chungnam National University)
Lee Hyeong-Kyu (College of Pharmacy, Catholic University of Daegu)
Sok Dai-Eun (College of Pharmacy, Chungnam National University)
Kim Mee Ree (Department of Food Science and Nutrition, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.28, no.9, 2005 , pp. 1023-1026 More about this Journal
Abstract
A new furofuran lignan (1) was isolated from the n-butanol fraction of the methanolic extract of the leaves of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae). The structure of compound 1 was determined to be $2{\alpha}-(4 by spectroscopic methods including 2D-NMR. In further studies, it was found that the compound 1 expressed an antioxidant activity in DPPH radical scavenging assay, and moreover, ameliorated the seizure in kainic acid-treated mice.
Keywords
Petasites japonicus; Petaslignolide A; Furofuran lignan; DPPH Radical scavenging; Antiseizure;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
연도 인용수 순위
1 Abe, F. and Yamauchi, T., 9$\alpha$-Hydroxypinoresinol, 9$\alpha$-hydroxymedioresinol and related lignans from Allamanda neriifolia. Phytochemistry, 27, 575-577 (1988)   DOI   ScienceOn
2 Lin, C. H., Li, C. Y., and Wu, T. S., A novel phenylpropenoyl sulfonic acid and a new chlorophyll from the leaves of Petasites formosanus Kitamura. Chem. Pharm. Bull., 52, 1151-1152 (2004)   DOI   ScienceOn
3 Mizushina, Y., Ishidoh, T., Kamisuki, S., Nakazawa, S., Takemura, M., Sugawara, F., Yoshida, H., and Sakaguchi, K., Flavonoid glycoside: A new inhibitor of eukaryotic DNA polymerase A and a new carrier for inhibitor-affinity chromatography. Biochem. Biophys. Res. Commun., 301, 480-487 (2003)   DOI   PUBMED   ScienceOn
4 Sok, D.-E., Oh, S. H., Kim, Y. B., and Kim, M. R., Neuroprotective effect of rough aster butanol fraction against oxidative stress in the brain of mice challenged with kainic acid. J. Agric. Food Chem., 51,4570-4575 (2003)   DOI   ScienceOn
5 Wang, G. J., Shum, A. Y., Lin, Y. L., Liao, J. F., Wu, X. C., Ren, J., and Chen, C. F., Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of Spetasin, a hypotensive sesquiterpene from Petasites formosanus. J. Pharmacol. Exp. Therap., 297, 240-246(2001)
6 Grossman, W. and Schmidramsl, H., An extract of Petasites hybridus is effective in the prophylaxis of migraine. Altern. Med. Rev., 6, 303-310 (2001)
7 Min, B. S., Nakamura, N., Miyashiro, H., Kim, Y. H., and Hattori, M., Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activities by Constituents of Juglans mandshurica. Chem. Pharm. Bull., 48, 194-200 (2000)   DOI   ScienceOn
8 Mohanan, P. V. and Yamamoto, H. A., Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicol. Lett., 129, 99-105 (2002)   DOI   PUBMED   ScienceOn
9 Lin, C. H., R. Li, C. Y., Kuoh, C. S., and Wu, T. S., Constituents from the leaves of Petasites formosanus and their antioxidant activity. Heterocycles, 60, 1881-1889 (2003)   DOI   ScienceOn
10 Khan, K. A. and Shoeb, A., A lignan from Lonicera hypoleuca. Phytochemistry, 24, 628-630 (1985)   DOI   ScienceOn
11 Hou, C. C., Lin, S. J., Cheng, J. T., and Hsu, F. L., Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. J. Nat. Prod., 66, 625-629 (2003)   DOI   ScienceOn
12 Ziolo, G. and Samochowiec, L., Study on clinical properties and mechanisms of action of Petasites in bronchial asthma and chronic obstructive bronchitis. Pharm. Acta Helv., 72, 378-380 (1998)
13 Mizushina, Y, Kamisuki, S., Kasai, N., Ishidoh, T, Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Yoshida, S., Koiwai, O., Sugawara, F, Yoshida, H., and Sakaguchi, K., Petasiphenol: A DNA polymerase I inhibitor. Biochemistry, 41, 14463-14471 (2002)   DOI   PUBMED   ScienceOn
14 Blois, M. S., Antioxidant determination by the use of a stable free radical. Nature, 181, 1199-1201 (1958)   DOI   ScienceOn
15 Yeo, H., Chin, Y. W., Park, S. Y., and Kim, J., Lignans of Rosa multiflora roots. Arch. Pharm. Res., 27, 287-290 (2004)   DOI   ScienceOn