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Structure and Antiinflammatory Activity Relationships of Wogonin Derivatives  

Jang, Jin-Hee (College of Pharmacy, Kangwon National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Park, Hae-Il (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.28, no.8, 2005 , pp. 877-884 More about this Journal
Abstract
A number of wogonin derivatives have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of $PGE_2$ production. Wogonin derivatives modified at the B ring of wogonin were obtained from 2,4-Dihydroxy-3,6-dimethoxyacetophenone (1) via several steps. Most wogonin derivatives exhibited much reduced inhibitory activities against COX-2 catalyzed $PGE_2$ production compared to that of wogonin. Alkylation of 5,7-phenol groups and substitution at the B ring of wogonin generally caused reduction of inhibitory activity.
Keywords
Wogonin derivatives; COX-2; Prostaglandin production inhibition; Anti-inflammatory activity;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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