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Synthesis and Antifungal Activity of Naphthalene-1,4-diones Modified at Positions 2, 3, and 5  

Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University)
Chae, Mi-Jin (College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.28, no.7, 2005 , pp. 750-755 More about this Journal
Abstract
A series of 2-arylamino-5-hydroxy-naphthalene-1,4-diones, 3-arylamino-5-methoxy-naphthalene-1,4-diones, and 2-arylamino-3chloro-5-hydroxy-naphthalene-1,4-diones were synthesized and tested for in vitro antifungal activity against the species Candida and Aspergillus niger. Among those tested, 3-arylamino-5-methoxy-naphthalene-1,4-diones exhibited potent antifungal activity. In general, the 3-arylamino-5-methoxy-naphthalene-1,4-diones showed more potent antifungal activity than the 2-arylamino-5-hydroxy-naphthalene-1,4-diones and the 2-arylamino-3-chloro-5-hydroxy-naphthalene-1,4-diones.
Keywords
5-Methoxy-naphthalene-1,4-diones; Antifungal; MIC; Candida species; A. niger;
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Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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