Browse > Article

Polymorphism of Doxazosin Mesylate  

Sohn Young-Taek (College of Pharmacy, Duksung Women's University)
Lee Yoon-Hee (College of Pharmacy, Duksung Women's University)
Publication Information
Archives of Pharmacal Research / v.28, no.6, 2005 , pp. 730-735 More about this Journal
Abstract
Nine polymorphic modifications of doxazosin mesylate have been obtained by recrystallization in organic solvents under variable conditions. Different polymorphs of doxazosin mesylate were characterized by powder X-ray crystallography diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). Transformation of Form 1 and Form 2 was not occurred in three relative humidities ($0\%$, $51\%$, and $99\%$) at 20$\pm$0.5 for 30 days.
Keywords
Doxazosin mesylate; Polymorphism; PXRD; DSC; TG; Transformation;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
연도 인용수 순위
1 Grcman, M., Vrecer, F., and Meden, A., Some physico-chemical properties of Doxazosin mesylate polymorphic forms and its amorphous state. J. Therm. Anal. Cal., 68, 373-387 (2002)   DOI   ScienceOn
2 Sun, C. and Grant, D. J. W., Influence of crystal structure on the tableting properties of sulfamerazine polymorphs. Pharm. Res., 18, 274-280 (2001)   DOI   ScienceOn
3 Gruenenberg, A., Polymorphie und thermische Analyse pharmazeutischer Wirkstoffe. Pharmazie in unserer Zeit, 26, 224-231 (1997)   DOI   PUBMED   ScienceOn
4 Giron, D., Thermal analysis and calorimetric methods in the characterization of polymorphs and solvates. Thermochim. Acta, 248, 1-59 (1995)   DOI   ScienceOn
5 Yoshinari, T., Forbes, R. T., York, P., and Kawashima, Y., The improved compaction properties of mannitol after a moistureinduced polymorphic transition. Int. J. Pharm., 258, 121-131 (2003)   DOI   PUBMED   ScienceOn
6 Borka, L., Reviews on crystal polymorphism of substances in the European Pharmacopoeia. Pharm. Acta Helv., 66, 16-22 (1991)
7 Sohn, Y. T., Effect of polymorphism on bioavailability of amoxicillin. Yakhak Hoeji, 39, 438-443 (1995)
8 Haleblian, J., Characterization of habits and crystalline modification of solids and their pharmaceutical applications. J. Pharm. Sci., 64, 1269-1288 (1975)   DOI   PUBMED
9 Kuhnert-Brandstaetter, M., Polymorphie von Arzneistoffen und ihre Bedeutung in der pharmazeutischen Technologie. Informationsdienst A.P.V., 19, 73-90 (1973)
10 Sohn, Y. T. and Kim, S. Y., Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids. Arch. Pharm. Res., 25, 556-559 (2002)   DOI   ScienceOn
11 Haleblian, J. and McCrowne, W., Pharmaceutical applications of polymorphism. J. Pharm. Sci., 58, 911-929 (1969)   DOI   PUBMED
12 Giridhar, T., Reddy, R. B.. and Ramesh, C., Methods for the preparation of polymorphs of doxazosin mesylate. US 6,399,775 B1 (2002)