[ ] Phase Arrest of the Cell Cycle by a Ginseng Metabolite, Compound K, in U937 Human Monocytic Leukamia Cells |
Kang Kyoung Ah
(Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Kim Yeong Wan (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University) Kim Seung Uk (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University) Chae Sungwook (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University) Koh Young Sang (Department of Microbiology, College of Medicine and Applied Radiological Science Research Institute, Cheju National University) Kim Hee Sun (Department of Neuro-science, Ewha Womans University Medical School) Choo Min Kyung (Department of Microbial Chemistry, College of Pharmacy, Kyung Hee University) Kim Dong Hyun (Department of Microbial Chemistry, College of Pharmacy, Kyung Hee University) Hyun Jin Won (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University) |
1 | Chiariello, M., Gomez, E., and Gutkind, J. S., Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late phase. Biochem. J., 349, 869-876 (2000) DOI |
2 | Hasegawa, H., Sung, J. H., and Huh, J. D., Ginseng intestinal bacteria metabolite IH901 as a new antimetastatic agent. Arch. Pharm. Res., 20, 539-544 (1997) DOI ScienceOn |
3 | Ikezoe, T., Yang, Y., Taguchi, H., and Koeffler, H. P., JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). Br. J. Cancer, 90, 2017-2024 (2004) DOI ScienceOn |
4 | Kang, K., Lim, H. K., Kim, S. U., Kim, Y. W., Kim, W. T., Chung, H. S., Choo, M. K., Kim, D. H., Kim, H. S., Shim, M. J., Chung, M. H., and Hyun, J. W., Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells. J. Food Biochem., 29, 29-40 (2005) DOI ScienceOn |
5 | Karin, M. The regulation of AP-1 activity by mitogen activated protein kinases. J. Biol. Chem., 270, 16483-16486 (1995) DOI |
6 | Lee, B. H., Lee, S. J., Hur, J. H., Lee, S., Sung, J. H., Huh, J. D., and Moon, C. K., In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta. Med., 64, 500-503 (1998) DOI ScienceOn |
7 | Strasser, A., Harris, A. W., Jacks, T., and Cory, S., DNA damage can induce apoptosis in proliferating lymphoid cells via p53 independent mechanisms by Bcl-2. Cell, 79, 329-339 (1994) DOI ScienceOn |
8 | Zada, A. A., Singh, S. M., Reddy, V. A., Elsasser, A., Meisel, A., Haferlach, T., Tenen, D. G., Hiddemann, W., and Behre, G., Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation. Oncogene, 22, 2296-2308 (2003) DOI ScienceOn |
9 | Demers, G. W., Foster, S. A., Halbert, C. L., and Galloway, D. A., Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc. Natl. Acad. Sci. U.S.A., 91, 4382-4326 (1994) DOI ScienceOn |
10 | Hasegawa, H., Sung, J. H., Matsumiya, S., and Uchiyama, M., Main ginseng saponin metabolites formed by intestinal bacteria. Planta. Med., 62, 453-457 (1996) DOI ScienceOn |
11 | Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth., 139, 271-279 (1991) DOI ScienceOn |
12 | Robinson, M. J. and Cobb, M. H. Mitogen activated protein kinase pathways. Curr. Opin. Cell Biol., 9, 180-186 (1997) DOI ScienceOn |
13 | Kim, H. S., Seo, H., Yang, C., and Kim, K. S., Noradrenergicspecific transcription of the dopamine -hydroxylase gene requires synergy of multiple cis-acting elements including at least two phox-2a binding sites. J. Neuroscience, 18, 8247-8260 (1998) |
14 | Oh, M., Choi, Y. H., Choi, S., Chung, H., Kim, K., Kim, S. I., Kim, D. K., and Kim, N. D., Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int. J. Oncol., 14, 869-875 (1999) |
15 | Moon, J., Yu, S. J., Kim, H. S., and Sohn J., Induction of G1 cell cycle arrest and p27 (KIP1) increase by panaxydol isolated from Panax ginseng. Biochem. Pharmacol., 59, 1109-1116 (2000) DOI ScienceOn |
16 | Hartwell, L. H. and Kastan, M. B., Cell cycle control and cancer. Science, 266, 1821-1828 (1994) DOI PUBMED |
17 | Yang, Y., Ikezoe, T., Saito, T., Kobayashi, M., Koeffler, H. P., and Taguchi, H., Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. Cancer Sci., 95, 176-180 (2004) DOI ScienceOn |
18 | Bunnett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sasata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., and Anderson, D. W., SP600125, an anthrapyrazolone inhibitor of Jun Nterminal kinase. Proc. Natl. Acad. Sci. U.S.A., 98, 13681-13686 (2001) DOI ScienceOn |
19 | Hasegawa, H., Sung, J. H., Matsumiya, S., Uchiyama, M., Inouye, Y., Kasai, R., and Yamasaki, K., Reversal of daunomycin and vinblastin resistance in multidrug resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. Planta. Med., 61, 409-413 (1995) DOI ScienceOn |
20 | McCubrey, J. A., May, W. S., Duronio, V., and Mufson, A., Serine/threonine phosphorylation in cytokine signal transduction. Leukemia, 14, 9-21 (2000) DOI ScienceOn |
21 | Pages, G., Lenomand, P., L'Allemania, G., Chambard, J. C., Meloche, S., and Pouyssegur, J., Mitogen activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. U.S.A., 90, 8319-8323 (1991) DOI |
22 | Fujita, M., Urano, T., Horie, K., Ikeda, K., Tsukui, T., Fukuoka, H., Tsutsumi, O., Ouchi, Y., and Inoue, S., Estrogen activates cyclin-dependent kinases 4 and 6 through induction of cyclin D in rat primary osteoblasts. Biochem. Biophys. Res. Commun., 299, 222-228 (2002) DOI ScienceOn |
23 | Widmann, C., Gibson, S., Jarpe, B., and Johnson, G. L., Mitogen activated protein kinase: conservation of a three kinase module from yeast to human. Physiol. Rev., 79, 143-180 (1999) DOI |
24 | Kim, S. E., Lee, Y. H., Park, J. H., and Lee S. K. Ginsenoside- Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells. Anticancer Res., 19, 487-491(1999) |
25 | Sugimoto, K., Toyoshima, H., Sakai, R., Miyakawa, K., Hagiwarw, K., Ishikawa, F., Takaku, F., Yazaki, Y., and Hirai, H., Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood, 79, 2378-2383 (1992) |
26 | Xiong, Y. G. J., Hannon, H., Zhang, D., Casso, R. K., and Beach, D., p21 is a universal inhibitor of cyclin kinases. Nature, 366, 701-704 (1993) DOI ScienceOn |
27 | Kim, J. Y., Lee, K. W., Kim, S. H., Wee, J. J., Kim, Y. S., and Lee H. J., Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol. Planta. Med., 68, 119-122 (2002) DOI ScienceOn |
28 | Slebos, R. J. C., Lee, M. H., Plunkett, B. S., Kessis, T. D., Williams, B. O., Jacks, T., Hedrick, L., Kastan, M. B., and Cho, K. R., p53 dependent G1 arrest involves pRB related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. U.S.A., 91, 5320-5324 (1994) DOI |
29 | Sheikh, M. S., Li, X. S., Chen, J. C., Shao, Z. M., Ordonez, J. V., and Fontana, J. A., Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53 dependent and independent signal transduction pathways. Oncogene, 9, 3407-3415 (1994) |
30 | Hasegawa, H., Matsumiya, S., Uchiyama, M., Kurokawa, T., Inouye, Y., Kasai, R., Ishibashi, S., and Yamasaki, K., Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta. Med., 60, 240-243 (1995) DOI ScienceOn |