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Protective Effects of Thiazolo[3,2-b]-1,2,4-Triazoles on Ethanol­Induced Oxidative Stress in Mouse Brain and Liver  

Aktay Goknur (Department of Pharmacology, Faculty of Pharmacy, Inonu University)
Tozkoparan Birsen (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University)
Ertan Mevlut (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University)
Publication Information
Archives of Pharmacal Research / v.28, no.4, 2005 , pp. 438-442 More about this Journal
Abstract
A series of 3-[1-(4-(2-methylpropyl) phenyl) ethyl]-1,2,4-triazole-5-thione (I) and its bicyclic condensed derivatives 6-benzylidenethiazolo[3,2-b]-1, 2,4-triazole-5(6H)-ones (IIa-IIf) were investigated for the prevention of ethanol-induced oxidative stress in liver and brain of mice. Administration of ethanol (0.1 mL/mice, p.o.) resulted in a drop of total thiol groups (T-SH) and non-protein thiol groups (NP-SH), and an increase in thiobarbituric acid reactive substances (TBARS) in both liver and brain tissue of mice (p<0.001). Among the compounds investigated (at a dose of 200 mg/kg, p.o.), I and IId ameliorated the peroxidative injury in these tissues effectively. Compounds IIa, IIc and IIe improved the peroxidative tissue injury only in brain. These findings suggest that certain condensed thiazolo-triazole compounds may contribute to the control of ethanol-induced oxidative stress in an organ selective manner.
Keywords
Antioxidant activity; Condensed thiazolo-triazole compounds; Ethanol toxicity; Non-steroidal antiinflammatory drugs; Oxidative stress;
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