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Monoamine Oxidase Inhibitory Naphthoquinones from the Roots of Lithospermum erythrorhizon  

Choi Woo Hoi (College of Pharmacy, Chungbuk National University)
Hong Seong Su (College of Pharmacy, Chungbuk National University)
Lee Seon A (College of Pharmacy, Chungbuk National University)
Han Xiang Hua (College of Pharmacy, Chungbuk National University)
Lee Kyong Soon (College of Pharmacy, Chungbuk National University)
Lee Myung Koo (College of Pharmacy, Chungbuk National University, Research Center for Biore-source and Health, Chungbuk National University)
Hwang Bang Yeon (College of Pharmacy, Chungbuk National University)
Ro Jai Seup (College of Pharmacy, Chungbuk National University)
Publication Information
Archives of Pharmacal Research / v.28, no.4, 2005 , pp. 400-404 More about this Journal
Abstract
Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with $IC_{50}$ values of 10.0, 13.3, and $59.1 {\mu}M$, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity.
Keywords
Lithospermum erythrorhizon; Boraginaceae; Naphthoquinone; Monoamine oxidase inhibitor;
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