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Antiinflammatory Constituents from the Roots of Smilax bockii warb.  

Xu Jing (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
Li Xian (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
Zhang Peng (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
Li Zhan-Lin (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
Wang Yi (Research Department of Natural Medicine, Shenyang Pharmaceutical University)
Publication Information
Archives of Pharmacal Research / v.28, no.4, 2005 , pp. 395-399 More about this Journal
Abstract
From $70\%$ ethanol extract of the roots of Smilax bockii warb., seven flavonoids, kaempferol (1), $kaempferol-7-O-\beta-D-glucopyranoside$ (2), quercetin (3), isorhamnetin (4), (+)-dihydro­kaempferol (5), engeletin (6), isoengeletin (7), and $n-butyl-\beta-D-fructopyranoside$ (8), caffeic acid n-butyl ester (9) were isolated and identified by means of chemical and spectroscopic. Compounds 2, 4, and 6-9 were isolated for the first time from the roots of S. bockii and compounds 2, 8, and 9 were firstly isolated from the genus Smilax. In addition, using the SEAP (Secreted alkaline phosphatase) assay system, we investigated the in vitro anti-inflammatory activity of the $70\%$ ethanol extract of the roots of S. bockii, which showed moderate activity in inhibiting $TNF-\alpha-induced NF-{\kappa}B$ activation with an $IC_{50}$ value of $166.6 {\mu}g/mL$.
Keywords
Smilax bockii warb.; Flavonoids; Caffeic acid n-butyl ester; Anti-inflammation activity;
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Times Cited By Web Of Science : 18  (Related Records In Web of Science)
Times Cited By SCOPUS : 18
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