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Synthesis of 3-Alkylthio-6-Allylthiopyridazine Derivatives and Their Antihepatocarcinoma Activity  

Kwon Soon-Kyoung (College of Pharmacy, Duksung Women's University)
Moon Aree (College of Pharmacy, Duksung Women's University)
Publication Information
Archives of Pharmacal Research / v.28, no.4, 2005 , pp. 391-394 More about this Journal
Abstract
The allylthio group of allicin and other organosulfur compounds, isolated from garlic, is considered a pharmacophore, and a key structure component of the molecule, which affords biological activities. In the foregoing studies, various 3-alkoxy-6-allylthiopyridazine derivatives (K­compounds) were synthesized, and their biological activities tested in animals. As expected, the various derivatives showed good hepatoprotective activities on carbon tetrachloride-treated mice and aflatoxin B1-treated rats, and chemopreventive activities on hepatocarcinoma cells in rats. Other new pyridazine derivatives, with the oxygen atom at the 3-position of the 3-alkoxy­6-allylthiopyridazine displaced by sulfur (S), were synthesized, and their activities tested in vitro. Thio-K6, one of the sulfur-substituted compounds, showed better chemopreventive activity toward hepatocarcinoma cells.
Keywords
Pyridazine; Allylthiopyridazine; Allicin; Organosulfur compounds; K-6; K-16; K-17; Thio-K Compound; Antihepatocarcinoma; Chemopreventive;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 12  (Related Records In Web of Science)
Times Cited By SCOPUS : 13
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