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Potentially Bioactive Two New Natural Sesquiterpenoids from the Rhizomes of Zingiber zerumbet  

Jang Dae Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Seol Eun Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.28, no.3, 2005 , pp. 294-296 More about this Journal
Abstract
Repeated chromatography of the n-hexane-soluble fraction of the MeOH extract of the rhizomes of Zingiber zerumbet led to the isolation of two isomers of 6-methoxy-2E,9E-humula-dien-8-one (1 and 2) and stigmast-4-en-3-one. The structures of 1 and 2 were determined by spectroscopic methods including 10 and 2D-NMR elucidated by analysis of spectroscopic data as well as by comparison with published values. This is the first report on the isolation of compounds 1 and 2 from the nature. Stigmast-4-en-3-one was first isolated from this plant.
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