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Cytotoxic Constituents of the Octocoral Dendronephthya gigantea  

Han Ah Reum (College of Pharmacy, Ewha Womans University)
Song Jun Im (College of Natural Science, Ewha Womens University)
Jang Dae Sik (Department of Herbal Parmaceutical Development, Korea Institute of Oriental Medicine)
Min Hye Young (College of Pharmacy, Ewha Womans University)
Lee Sang Kook (College of Pharmacy, Ewha Womans University)
Seo Eun Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.28, no.3, 2005 , pp. 290-293 More about this Journal
Abstract
A known monoalkyl glycerol ether, ($\pm$)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (28,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1 ,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.
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1 McLafferty, F. W., Mass spectrometric analysis: aliphatic ethers. Anal. Chem., 29, 1782-1789 (1957)   DOI
2 Mizobuchi, S., Shimidzu, N., Katsuoka, M., Adachi, K., and Miki, W., Chemical studies on antifouling substances in marine invertebrates - Part 1. Antifouling substances against the mussel in an octocoral Dendronephthya sp. Nippon Suisan Gakk., 59, 1195-1199 (1993)   DOI   ScienceOn
3 Rezanka, T. and Dembitsky, V. M., Brominated oxylipins and oxylipin glycosides from red sea corals. Eur. J. Org. Chem., 309-316 (2003)
4 Tomono, Y., Hirota, H., and Fusetani, N., Isogosterones A-D, antifouling 13,17-secosteroids from an octocoral Dendronephthya sp. J. Org. Chem., 64, 2272-2275 (1999a)   DOI   ScienceOn
5 Kawamata, M., Kon-ya, K., and Miki, W., Trigonelline, an antifouling substance isolated from an octocoral Dendronephthya sp. Fisheries Sci., 60, 485-486 (1994)   DOI
6 Harder, T., Lau, S. C. K., Dobretsov, S., Fang, T. K., and Qian, P.-Y., A distinctive epibiotic bacterial community on the soft coral Dendronephthya sp. and antibacterial activity of coral tissue extracts suggest a chemical mechanism against bacterial epibiosis. FEMS. Microbiol. Ecol., 43, 337-347 (2003)   DOI   ScienceOn
7 Quijano, L., Cruz, F., Navarrete, I., Gomez, P., and Rios, T., Alkyl glycerol monoethers in the marine sponge Desmapsamma anchorata. Lipids, 29, 731-734 (1994)   DOI   ScienceOn
8 Lee, S. K., Cui., B., Mehta, R. R., Kinghorn, A. D., and Pezzuto, J. M., Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica. Chemico-Biol. Interact., 115, 215-228 (1998)   DOI   ScienceOn
9 Seo, Y., Cho, K. W., Lee, H.-S., Rho, J.-R., and Shin, J., New acetylenic enol ethers of glycerol from the sponge Petrosia sp. J. Nat. Prod., 62, 122-126 (1999)   DOI   ScienceOn
10 Tomono, Y., Hirota, H., Imahara, Y., and Fusetani, N., Four new steroids from two octocorals. J. Nat. Prod., 62, 1538-1541 (1999b)   DOI   ScienceOn
11 Miki, W., Kon-ya, K., and Mizobuchi, S., Biofouling and marine biotechnology: new antifoulants from marine invertebrates. J. Mar. Biotechnol., 4, 117-120 (1996)
12 Ouwerkerk, N., Steenweg, M., de Ruijter, M., Brouwer, J., van Boom, J. H., Lugtenburg, J., and Raap, J., One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose- 5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides. J. Org. Chem., 67, 1480- 1489 (2002)   DOI   ScienceOn
13 Newman, D. J. and Cragg, G. M., Marine natural products and related compounds in clinical and advanced preclinical trials. J. Nat. Prod., 67, 1216-1238 (2004)   DOI   ScienceOn
14 Pavia, D. L., Lampman, G. M., and Kriz, G. S., Introduction to spectroscopy: A guide for students of organic chemistry. Brooks Cole, USA (2001)
15 Yoshikawa, K., Kanekuni, S., Hanahusa, M., Arihara, S., and Ohta, T., Polyhydroxylated sterols from the octocoral Dendronephthya gigantea. J. Nat. Prod., 63, 670-672 (2000)   DOI   ScienceOn
16 Shin, J. and Seo, Y., Isolation of new ceramides from the gorgonian Acabaria undulata. J. Nat. Prod., 58, 948-953 (1995)   DOI   ScienceOn