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New Cytotoxic Sulfated Saponins from the Starfish Certonardoa semiregularis  

Wang Wei Hong (College of Pharmacy, Pusan National University)
Jang Hyo Jin (College of Pharmacy, Pusan National University)
Hong Jong Ki (Basic Science Institute)
Lee Chong Ok (Korea Research Institute of Chemical Technology)
Bae Song Ja (Silla University)
Shin Sook (Sahmyook University)
Jung Jee H. (College of Pharmacy, Pusan National University)
Publication Information
Archives of Pharmacal Research / v.28, no.3, 2005 , pp. 285-289 More about this Journal
Abstract
Two new sulfated saponins designated as certonardosides P$_{2}$ and I$_{3}$ (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.
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