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Inhibitory Activity of Isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase  

Oh Hyun Mi (Korea Research Institute of Bioscience and Biotechnology, KIST)
Kwon Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST)
Baek Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Kim Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University)
Chung In-Sik (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Park Mi-Hyun (Erom Life Co. Ltd.)
Park Hee Wook (College of Pharmacy, Woosuk University)
Lee Jae Hyeok (College of Pharmacy, Woosuk University)
Park Hye Won (College of Pharmacy, Woosuk University)
Kim Eun Jeong (College of Pharmacy, Woosuk University)
Kim Dae Keun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.28, no.2, 2005 , pp. 169-171 More about this Journal
Abstract
The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of isorhamnetin was $37.5\;{\mu}M$.
Keywords
Persicaria thunbergii; FPTase; Isorhamnetin;
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