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Inhibition of Calmodulin-Dependent Protein Kinase II by Cyclic and Linear Peptide Alkaloids from Zizyphus Species  

Han Yong Nam (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Hwang Keum Hee (Korea Bio-Food and Drug Research Center, Konkuk University)
Han Byung Hoon (Natural Products Research Institute, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.28, no.2, 2005 , pp. 159-163 More about this Journal
Abstract
The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated. Protein kinase II activity was assayed on the basis of its ability to activate tryptophan 5-monooxygenase as its substrate in the presence of calmodulin. All thirteen alkaloids tested were stronger inhibitors than chlorpromazine ($IC_50,\;98{\mu}M$) on calmodulin-dependent protein kinase II. Among them, the most potent inhibitor was daechuine S27 ($IC_{50},\;2.95{\mu}M$), which was stronger than pimozide ($IC_{50},\;15.0{\mu}M$).
Keywords
Zizyphus alkaloids; Calmodulin-dependent protein kinase II; Peptide alkaloid; Calmodulin; Rhamnaceae;
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Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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