BMS-191095, a Cardioselective Mitochondrial ![]() ![]() |
Cho Mi-Ra
(College of Pharmacy, Chungbuk National University)
Park Jung-Wook (Division of Life Science, College of Natural Sciences, Konkuk University) Jung In-Sang (Division of Life Science, College of Natural Sciences, Konkuk University) Yi Kyu-Yang (Medical Science Division, Korea Research Institute of Chemical Technology) Yoo Sung-Eun (Medical Science Division, Korea Research Institute of Chemical Technology) Chung Hun-Jong (Pediatric Department, Chungju Hospital, Konkuk Medical School, Konkuk University) Yun Yeo-Pyo (College of Pharmacy, Chungbuk National University) Kwon Suk-Hyung (Rexgene Biotech Co. Ltd.,) Shin Hwa-Sup (Division of Life Science, College of Natural Sciences, Konkuk University) |
1 |
Andersson, T. L. and Vinge, E., The efflux of |
2 | de Silva, H. A., Carver, J. G., and Aronson, J. K., Pharmacological evidence of calcium-activated and voltage-gated potassium channels in human platelets. Clin. Sci. (Lond), 93, 249-255 (1997) |
3 | Kaeffer, N., Richard, V., Francois, A, Lallemand, F., Henry, J. P., and Thuillez, C., Preconditioning prevents chronic reperfusioninduced coronary endothelial dysfunction in rats. Am. J. Physiol., 271, H842-849 (1996) |
4 | Maruyama, Y., A patch-clamp study of mammalian platelets and their voltage-gated potassium current. J. Physiol., 391, 467- 485 (1987) |
5 | Nakai, Y., Horimoto, H., Mieno, S., and Sasaki, S., Mitochondrial ATP-sensitive potassium channel plays a dominant role in ischemic preconditioning of the rabbit heart. Eur. Surg. Res., 33, 57-63 (2001) DOI ScienceOn |
6 | Park, Y. S., Yoo, S. E., Shin, H. S., Jin, Y. R., and Yun, Y. P., Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta. J. Pharmacol. Sci., 92, 218-227 (2003) DOI ScienceOn |
7 | Shin, H. S., Seo, H. W., Oh, J. H., and Lee, B. H., Antihypertensive effects of the novel potassium channel activator SKP- 450 and its major metabolites in rats. Arzneimittelforschung, 48, 969-978 (1998a) |
8 | Yellon, D. M., Alkhulaifi, A. M., Browne, E. E., and Pugsley, W.B., Ischaemic preconditioning limits infarct size in the rat heart. Cardiovasc. Res., 26, 983-987 (1992) DOI ScienceOn |
9 | Pearson, P. J., Schaff, H. V., and Vanhoutte, P. M., Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries. Circulation, 81, 1921-1927(1990) DOI ScienceOn |
10 | Yellon, D. M., Alkhulaifi, A. M., and Pugsley, W. B., Preconditioning the human myocardium. Lancet, 342, 276-277 (1993) DOI ScienceOn |
11 | Rovnyak, G. C., Ahmed, S. Z., Ding, C. Z., Dzwonczyk, S., Ferrara, F. N., Humphreys, W. G., Grover, G. J., Santafianos, D., Atwal, K. S., Baird, A. J., McLaughlin, L. G., Normandin, D. E., Sleph, P. G., and Traeger, S. C., Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity. J. Med. Chem., 40, 24-34 (1997) DOI ScienceOn |
12 |
D'Alonzo, A. J., Grover, G. J., Darbenzio, R. B., Sewter, J. C., Hess, T. A., Dzwonczyk, S., and Sleph, P. G., Hemodynamic and cardiac effects of BMS-180448, a novel |
13 | Edwards, G. and Weston, A. H., Recent advances in potassium channel modulation. Prog. Drug Res., 49, 93-121 (1997) |
14 | Laude, K., Beauchamp, P., Thuillez, C., and Richard, V., Endothelial protective effects of preconditioning. Cardiovasc. Res., 55, 466-473 (2002) DOI ScienceOn |
15 |
Grover, G. J. and Atwal, K. S., Pharmacologic profile of the selective mitochondrial- |
16 | Grover, G. J., D'Alonzo, A. J., Hess, T., Sleph, P. G., and Darbenzio, R. B., Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening. Cardiovasc. Res., 30, 731-738 (1995) |
17 | Kinoshita, H., Iwahashi, S., Kakutani, T., Mizumoto, K., Iranami, H., and Hatano, Y., The role of endothelium-derived nitric oxide in relaxations to levcromakalim in the rat aorta. Jpn. J. Pharmacol., 81, 362-366 (1999) DOI ScienceOn |
18 | Kleiman, N. S., GP IIb/IIIa antagonists. Clinical experience and potential uses in cardiology. Drugs R. D., 1, 361-370 (1999) DOI PUBMED ScienceOn |
19 | Seligmann, C., Schimmer, M., Leitsch, T., Bock, A., Simsek, Y., Tschope, C., and Schultheiss, H. P., A thrombocyte-induced myocardial dysfunction in the ischemic and reperfused guinea pig heart is mediated by reactive oxygen species. Free Radic. Biol. Med., 29, 1244-1251 (2000) DOI ScienceOn |
20 | Kawa, K., Voltage-gated calcium and potassium currents in megakaryocytes dissociated from guinea-pig bone marrow. J. Physiol., 431, 187-206 (1990) |
21 | Shin, H. S., Seo, H. W., Yoo, S. E., and Lee, B. H., Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310. Pharmacology, 56, 111-124 (1998b) DOI ScienceOn |
22 |
Kapural, L. and Fein, A., Suppression of the voltage-gated |
23 |
Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Sun, X., and Schindler, P. A., The mitochondrial |
24 |
Jung, Y. S., Moon, C. H., Cho, T. S., Yoo, S. E., and Shin, H. S., Cardioprotective effects of KR-30450, a novel |
25 | Lee, B. H., Seo, H. W., Yoo, S. E., Kim, S. O., Lim, H., and Shin, H. S., Differential action of KR-31378, a novel potassium channel activator, on cardioprotective and hemodynamic effects. Drug Dev. Res., 54, 182-190 (2001) DOI ScienceOn |
26 | Ku, D. D., Coronary vascular reactivity after acute myocardial ischemia. Science, 218, 576-578 (1982) DOI PUBMED |
27 | Seligmann, C., Simsek, Y., Schimmer, M., Leitsch, T., Bock, A., and Schultheiss, H. P., Human thrombocytes are able to induce a myocardial dysfunction in the ischemic and reperfused guinea pig heart mediated by free radicals-role of the GPIIb/IIIa-blocker tirofiban. Life Sci., 71, 2319-2329 (2002) DOI ScienceOn |
28 | Atwal, K. S., Grover, G. J., Ahmed, S., Ferrara, F. N., Harper, T. W., Kim, K. S., Sleph, P. G., Dzwonczyk, S., Russell, A. D., Moreland, S., et al., Cardioselective anti-ischemic ATPsensitive potassium channel openers. J. Med. Chem., 36, 3971-3974 (1993) DOI ScienceOn |
29 | Teshima, Y., Akao, M., Li, R. A., Chong, T. H., Baumgartner, W. A., Johnston, M. V., and Marban, E., Mitochondrial ATPsensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke, 34, 1796-1802 (2003) DOI ScienceOn |
30 | Grover, G. J., D'Alonzo, A. J., Darbenzio, R. B., Parham, C. S., Hess, T. A., and Bathala, M. S., In vivo characterization of the mitochondrial selective K(ATP) opener (3R)-trans-4-((4- chlorophenyl)-N-(1H-imidazol-2-ylmethyl)dimethyl-2H-1- benzopyran-6-carbonitril monohydrochloride (BMS-191095): cardioprotective, hemodynamic, and electrophysiological effects. J. Pharmacol. Exp. Ther., 303, 132-140 (2002) DOI ScienceOn |
31 | Li, Y. and Kloner, R. A., Cardioprotective effects of ischaemic preconditioning are not mediated by prostanoids. Cardiovasc. Res., 26, 226-231 (1992) DOI ScienceOn |
32 | de Silva, H. A., Aronson, J. K., Grahame-Smith, D. G., Jobst, K. A., and Smith, A. D., Abnormal function of potassium channels in platelets of patients with Alzheimer's disease. Lancet, 352, 1590-1593 (1998) DOI ScienceOn |
33 | Van Benthuysen, K. M., McMurtry, I. F., and Horwitz, L. D., Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J. Clin. Invest., 79, 265-274 (1987) DOI |
34 |
Grover, G. J., D'Alonzo, A. J., Garlid, K. D., Bajgar, R., Lodge, N. J., Sleph, P. G., Darbenzio, R. B., Hess, T. A., Smith, M. A., Paucek, P., and Atwal, K. S., Pharmacologic characterization of BMS-191095, a mitochondrial |
35 |
Kapural, L., Feinstein, M. B., O'Rourke, F., and Fein, A., Suppression of the delayed rectifier type of voltage gated |
36 | Armstrong, S. C., Liu, G. S., Downey, J. M., and Ganote, C. E., Potassium channels and preconditioning of isolated rabbitcardiomyocytes: Effects of glyburide and pinacidil. J. Mol. Cell Cardiol., 27, 1765-1774 (1995) DOI ScienceOn |
37 | Habazettl, H., Hanusch, P., and Kupatt, C., Effects of endothelium/ leukocytes/platelet interaction on myocardial ischemia-- reperfusion injury. Z. Kardiol., 89(Suppl 9), IX/92-95 (2000) DOI ScienceOn |
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