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Immunobioloical Activity of a New Benzyl Benzoate from the Aerial Parts of Solidago virga-aurea var. gigantea  

Choi Sang Zin (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University)
Choi Sang Un (Korea Research Institute of Chemical Technology)
Bae Seong Yun (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University)
Pyo Suhk neung (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University)
Lee Kang Ro (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University)
Publication Information
Archives of Pharmacal Research / v.28, no.1, 2005 , pp. 49-54 More about this Journal
Abstract
The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea Mo. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxy­benzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6­hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro usingherapeutic agents by stimulating macrophage functions, with potential use in the treat­ mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.
Keywords
Solidago virga-aurea var. gigantea; Compositae; Benzyl benzoates; Macrophage;
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
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