Browse > Article

A New Antipsychotic Effective Neolignan from Firmiana simplex  

Son Yeon Kyoung (Natural Products Research Institute Seoul National University)
Lee Ming Hong (Natural Products Research Institute Seoul National University)
Han Yong Nam (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.28, no.1, 2005 , pp. 34-38 More about this Journal
Abstract
A new neolignan, named simplidin was isolated from the n-butanol extract of stem of Firmiana simplex, together with six known compounds, scopoletin (1), syrigaresinol (2), aquillochin (3), nitidanin (4), tamarixetin 3-rhamnoside (6), and quercitrin (7). On the basis of spectral and chemical evidence, simplidin (5) was determined to be rel-(7R, 8R)-4, 5, 9, 9'-tetrahydroxy-3,3'­dimethoxy-7-O-5', 8-O-4'-neolignan. All the six compounds were also isolated for the first time from this plant.
Keywords
Fimiana simplex; Sterculiaceae; Benzodioxane lignan; Neolignan; Antipsychotic effect;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
연도 인용수 순위
1 Bhandari, P, Pant, P., and Rastogi, R. P., Aquillochin, a coumarinolignan from Aquilaria agallocha. Phytochem., 21, 2147-2149 (1982)   DOI   ScienceOn
2 Ishikawa, T., Seki, M., Nishigaya, K., and Miura, Y., Studies on the chemical constituents of Xanthoxylum nididum (ROXB.) D. C. (Fagara nidida ROXB.). III. The chemical constituents of the wood. Chem. Pharm. Bull., 43, 2014-2018 (1995)   DOI
3 Lee, J. H., Ku, C. H., Baek, N. I., Kim, S. H., Park, H. W., and Kim, D. K., Phytochemical constituents from Diodia teres. Phytochem. Arch. Pharm. Res., 27, 40-43 (2004)   DOI   ScienceOn
4 LIn, T. C., Fang, J. M., and Cheng, Y. S., Terpenes and lignans from leaves of Chamaecyparis formosensis. Phytochem., 51, 793-801 (1999)   DOI   ScienceOn
5 Marita, J. M., Ralph, J., Hatafield, R. D., Guo, D., Chen, F., and Dixon, R. A., Structural and compositional modifications in lignin of transgenic alfalfa down-regulated in caffeic acid 3-O-methyltransferase and caffeoyl coenzyme A 3-O-methyltransferase. Phytochem., 62, 53-65 (2003)   DOI   ScienceOn
6 Rao, C. P., Hanumaiah, T., Venuri, V. S. S., and Rao, K. V. J., Flavonol 3-glycosides from the leaves of Flemingia stricta. Phytochem., 22, 621-622 (1983)   DOI   ScienceOn
7 Su, G. N., Yang, L., and Jia, Z. J., Neolignan, phenylpropanoid and iridoid glycosides from Pedicularis verticillata. Phytochem., 45, 1271-1273 (1997)   DOI   ScienceOn
8 Fang, J. M., Lee, C. K., and Cheng, Y. S., Lignans from leaves of Juniperus chinensis. Phytochem., 31, 3659-3661 (1992)   DOI   ScienceOn
9 Fournand, D., Cathala, B., and Lapierre, C., Initial steps of the peroxidase-catalyzed polymerization of coniferyl alcohol and/or sinapyl aldehyde: capillary zone electrophoresis study of pH effect. Phytochem., 62,139-1496 (2003)   DOI   ScienceOn
10 Prescott, G. P., Stamford, N. P. J., Wheeler, G., and Firmin, J. L., In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. Phytochem., 60, 589-593 (2002)   DOI   ScienceOn
11 Bae, K. H., Medicinal plants of Korea, KyoHak Publishing Co., Ltd. Seoul, pp. 336, (2000)
12 Bermes, B., Seligmann, O., and Wagner, H., Synthesis of biologically active tetrahydro-furofuranlignan-(syringin, pinoresinol)mono- and bis-glucosides. Phytochem., 30, 3087-3089 (1991)   DOI   ScienceOn
13 Hotta, M., Ogata, K., Nitta, A., Hosikawa, K., Yanagi, M., and Yamazaki K., Useful plant of the world, Heibonsha, Tokyo. pp. 461, (1989)
14 Ralph, J., Lapierre, C., Lu, F., Marita, M. M., Pilate, G., Doorsselaere, J. V., Boerjan, W., and Jouanin, L., NMR evidence for benzodioxane structures resulting from incorporation of 5-hydoxyconiferyl alcohol into lignins of 0methyltransferase-deficient poplars. J. Agric. Food Chem., 49, 86-91 (2001)   DOI   ScienceOn