Browse > Article

Antihistamine Effects of Triprolidine from the Transdermal Administration of the TPX Matrix in Rats  

Shin Sang-Chul (College of Pharmacy, Chonnam National University)
Choi Jun-Shik (College of Pharmacy, Chosun University)
Publication Information
Archives of Pharmacal Research / v.28, no.1, 2005 , pp. 111-114 More about this Journal
Abstract
The antihistamine effects of the triprolidine were studied in rats to determine the feasibility of their enhanced transdermal delivery from the poly (4-methyl-1-pentene) (TPX) matrix system containing penetration enhancer and plasticizer. The antihistamine effects were determined by the Evans blue dye procedure by comparing the changes in vascular permeability increase following the transdermal administration. The vascular permeability increase was significantly reduced by transdermal administration of the triprolidine-TPX system containing triethyl citrate (TEC) and polyoxyethylene-2-oleyl ether (POE). Both the plasticizer and penetration enhancer played an important role in the skin permeation of triprolidine and increased the antihistamine effects. These results showed that the triprolidine-TPX matrix system containing plasticizer and penetration enhancer could be a transdermal delivery system providing the increased antihistamine effects.
Keywords
Triprolidine; TPX; Antihistamine effects; Vascular permeability increase; Evans blue;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Shin, S. C. and Yoon, M. K., Application of TPX polymer membranes for the controlled release of triprolidine. Int. J. Pharm., 232, 131-137 (2002)   DOI   PUBMED   ScienceOn
2 Shin, S. C. and Choi, J. S., Enhanced bioavailability of triprolidine from the transdermal TPX matrix. Int. J. Pharm., 234, 67-73 (2002)   DOI   PUBMED   ScienceOn
3 Stevens, R. L. and Austen, J. F., Recent advances in the cellular and molecular biology of mast cells. Immunol. Today, 10, 381-386 (1989)   DOI   ScienceOn
4 Shin, S. C., Kim, J., Yoon, M. K., Oh, I. J., and Choi, J. S., Transdermal delivery of triprolidine using TPX polymer membrane. Int. J. Pharm., 235, 141-147 (2002)   DOI   PUBMED   ScienceOn
5 Morimoto, Y., Seki, T., Sugibayashi, K., Juni, K., and Miyazaki, S., Basic studies on controlled transdermal delivery of nicardipine hydrochloride using ethylene-vinyl acetate and ethylene-vinyl alcohol copolymer membranes. Chem. Pharm. Bull., 36, 2633-2641 (1988)   DOI   ScienceOn
6 Katayama, S., Shionoya. H., and Ohtake, S., A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. Microbiol. Immunol., 22, 89-101 (1978)
7 Hadgraft, J., 'Transdermal drug delivery', Marcel Dekker, Inc., New York and Basel, pp. 298-300 (1987)
8 Inagaki. N., Miura, T., Nagai, H., Ono, Y., and Koda, A., Inhibition of vascular permeability increase in mice - An addition anti-allergic mechanism of glucocorticoids. Int. Arch. Allergy Appl. Immunol., 87, 254-259 (1998)
9 Holgate, S. T., The mast cell and its function in allergic disease. Clin. Exp. Allergy, 21, 11-16 (1991)   DOI   ScienceOn
10 Ocak, F. and Agabeyoglu, I., Development of a membranecontrolled transdermal therapeutic system containing isosorbide dinitrate. Int. J. Pharm., 180, 177-183 (1999)   DOI   ScienceOn
11 Chien, Y. W., 'Transdermal controlled systemic medications', Marcel Dekker, Inc., New York and Basel, pp. 132-137 (1987)
12 Gennaro, A. R., Remington (Eds.). The science and practice of pharmacy. 19th ed., Mack publishing company, Easton, PA, pp. 1207-1218 (1995)